Gene info
HGNC approved symbolCHD6
HGNC IDHGNC:19057
HGNC approved namechromodomain helicase DNA binding protein 6
Entrez gene IDGeneID:#
(SSTAR profile)
UniProt AC (human)Q8TD26
UniProt ID (human)CHD6_HUMAN
Pfam domainsBRK PF07533 (2400-2441)
Chromo PF00385 (292-354, 375-429)
Helicase_C PF00271 (817-897)
Pfam-B_18962 PB018962 (1-49)
Pfam-B_23619 PB023619 (1691-1909)
Pfam-B_71010 PB071010 (1911-1953)
Pfam-B_761 PB000761 (1271-1333, 1361-1519)
SNF2_N PF00176 (464-751)
MGI symbolChd6
MGI IDMGI:1918639
UniProt AC (mouse)A3KFM7
UniProt ID (mouse)CHD6_MOUSE
HGNC gene family tag#
HGNC gene family description#
FunctionChromatin remodeling
Modification#
PMID for information on functionPMID:12592387
Protein complex#
Target moleculechromatin
Target entity#
Product#
PMID for information on targetPMID:12592387
CommentA novel gene encoding a protein with chromatin remodeling, helicase and DNA-binding motifs. This gene (CHD5=CHD6) is the fifth member of the CHD gene family identified in humans.
Status of entry#

Expression statistics
Expression range: 1.04 to 182.92
Mean expression: 30.16 ± 22.13
Median expression: 24.67
Sample class Sample Expression (RLE-normalized CAGE tags per million)
Quantile over all genes
cell_line gastrointestinal carcinoma cell line:ECC12.CNhs11738.10615-108G3 182.9 0.901
cell_line breast carcinoma cell line:MCF7.CNhs11943.10482-107A5 121.9 0.867
cell_line small cell gastrointestinal carcinoma cell line:ECC10.CNhs11736.10610-108F7 111.4 0.854
cell_line small-cell gastrointestinal carcinoma cell line:ECC4.CNhs11734.10609-108F6 91.2 0.858
cell_line maxillary sinus tumor cell line:HSQ-89.CNhs10732.10414-106B9 90.9 0.847
cell_line Hodgkin's lymphoma cell line:HD-Mar2.CNhs11715.10435-106E3 83.9 0.798
cell_line neuroblastoma cell line:CHP-134.CNhs11276.10508-107D4 81.0 0.809
cell_line non T non B acute lymphoblastic leukemia (ALL) cell line:P30/OHK.CNhs10747.10430-106D7 78.8 0.771
cell_line neuroectodermal tumor cell line:FU-RPNT-1.CNhs11744.10637-108I7 76.3 0.804
cell_line ductal cell carcinoma cell line:KLM-1.CNhs11100.10438-106E6 69.7 0.814
cell_line gastric adenocarcinoma cell line:MKN1.CNhs11737.10614-108G2 69.5 0.833
cell_line testicular germ cell embryonal carcinoma cell line:NEC15.CNhs12362.10593-108D8 68.6 0.769
cell_line pleomorphic hepatocellular carcinoma cell line:SNU-387.CNhs11933.10706-109H4 67.9 0.812
cell_line acute lymphoblastic leukemia (T-ALL) cell line:HPB-ALL.CNhs10746.10429-106D6 65.5 0.753
cell_line breast carcinoma cell line:MDA-MB-453.CNhs10736.10419-106C5 64.0 0.772
cell_line merkel cell carcinoma cell line:MKL-1.CNhs12838.10843-111E6 61.4 0.748
cell_line hepatoblastoma cell line:HuH-6.CNhs11742.10633-108I3 60.6 0.717
cell_line anaplastic carcinoma cell line:8305C.CNhs10745.10428-106D5 60.3 0.828
cell_line argyrophil small cell carcinoma cell line:TC-YIK.CNhs11725.10589-108D4 57.7 0.792
cell_line glioblastoma cell line:A172, tech_rep1.CNhs11185.10444-106F3 57.6 0.781
cell_line neuroblastoma cell line:NH-12.CNhs11811.10555-107I6 57.6 0.741
cell_line osteosarcoma cell line:143B/TK^(-)neo^(R).CNhs11279.10510-107D6 54.5 0.721
cell_line lung adenocarcinoma cell line:PC-14.CNhs10726.10408-106B3 53.6 0.735
cell_line cord blood derived cell line:COBL-a 24h infection(-C).CNhs11049.10452-106G2 50.7 0.684
cell_line small cell lung carcinoma cell line:WA-hT.CNhs11812.10562-108A4 50.3 0.716
cell_line acute myeloid leukemia (FAB M7) cell line:M-MOK.CNhs13049.10699-109G6 49.3 0.686
cell_line glioblastoma cell line:A172, tech_rep2.CNhs11248.10444-106F3 49.2 0.749
cell_line malignant trichilemmal cyst cell line:DJM-1.CNhs10730.10412-106B7 49.2 0.708
cell_line somatostatinoma cell line:QGP-1.CNhs11869.10781-110G7 49.0 0.763
cell_line serous cystadenocarcinoma cell line:HTOA.CNhs11827.10693-109F9 48.9 0.786
cell_line testicular germ cell embryonal carcinoma cell line:NEC14.CNhs12351.10591-108D6 48.6 0.681
cell_line clear cell carcinoma cell line:TEN.CNhs11930.10636-108I6 48.3 0.767
cell_line neuroectodermal tumor cell line:FU-RPNT-2.CNhs11753.10663-109C6 48.2 0.716
cell_line epidermoid carcinoma cell line:A431.CNhs10743.10426-106D3 47.7 0.726
cell_line splenic lymphoma with villous lymphocytes cell line:SLVL.CNhs10741.10424-106D1 47.7 0.711
cell_line retinoblastoma cell line:Y79.CNhs11267.10475-106I7 46.9 0.678
cell_line mesodermal tumor cell line:HIRS-BM.CNhs12191.10696-109G3 46.7 0.729
cell_line transitional-cell carcinoma cell line:5637.CNhs10735.10418-106C4 46.5 0.712
cell_line hepatocellular carcinoma cell line: HepG2 ENCODE, biol_rep3.CNhs12330.10820-111C1 46.2 0.708
cell_line testicular germ cell embryonal carcinoma cell line:NEC8.CNhs11726.10590-108D5 45.9 0.691
cell_line neuroblastoma cell line:NBsusSR.CNhs11818.10607-108F4 45.8 0.73
cell_line colon carcinoma cell line:CACO-2.CNhs11280.10513-107D9 45.7 0.726
cell_line medulloblastoma cell line:D283 Med.CNhs12805.10838-111E1 45.7 0.653
cell_line hairy cell leukemia cell line:Mo.CNhs11843.10712-109I1 45.5 0.717
cell_line choriocarcinoma cell line:BeWo.CNhs10740.10423-106C9 45.0 0.725
cell_line non-small cell lung cancer cell line:NCI-H1385.CNhs12193.10730-110B1 44.8 0.712
cell_line merkel cell carcinoma cell line:MS-1.CNhs12839.10844-111E7 43.6 0.674
cell_line large cell lung carcinoma cell line:IA-LM.CNhs11277.10509-107D5 43.5 0.716
cell_line small cell lung carcinoma cell line:NCI-H82.CNhs12809.10842-111E5 42.9 0.653
cell_line mesothelioma cell line:Mero-82.CNhs13069.10853-111F7 42.8 0.724
cell_line anaplastic squamous cell carcinoma cell line:RPMI 2650.CNhs11889.10805-111A4 42.4 0.645
cell_line hepatocellular carcinoma cell line: HepG2 ENCODE, biol_rep2.CNhs12329.10819-111B9 42.1 0.681
cell_line small cell cervical cancer cell line:HCSC-1.CNhs11885.10800-110I8 41.9 0.696
cell_line oral squamous cell carcinoma cell line:HSC-3.CNhs11717.10545-107H5 41.3 0.734
cell_line giant cell carcinoma cell line:Lu99B.CNhs10751.10433-106E1 40.6 0.717
cell_line oral squamous cell carcinoma cell line:Ca9-22.CNhs10752.10434-106E2 40.5 0.712
cell_line renal cell carcinoma cell line:OS-RC-2.CNhs10729.10411-106B6 40.2 0.729
cell_line sacrococcigeal teratoma cell line:HTST.CNhs11829.10695-109G2 40.1 0.719
cell_line endometrial carcinoma cell line:OMC-2.CNhs11266.10497-107C2 39.8 0.711
cell_line embryonic pancreas cell line:2C6.CNhs11814.10603-108E9 39.4 0.673
cell_line epidermoid carcinoma cell line:Ca Ski.CNhs10748.10431-106D8 39.3 0.67
cell_line gall bladder carcinoma cell line:TGBC14TKB.CNhs11256.10470-106I2 38.9 0.67
cell_line mesothelioma cell line:ACC-MESO-4.CNhs11264.10494-107B8 38.8 0.67
cell_line peripheral neuroectodermal tumor cell line:KU-SN.CNhs11830.10697-109G4 38.7 0.66
cell_line synovial sarcoma cell line:HS-SY-II.CNhs11244.10441-106E9 37.7 0.63
cell_line hepatocellular carcinoma cell line: HepG2 ENCODE, biol_rep1.CNhs12328.10818-111B8 37.3 0.653
cell_line colon carcinoma cell line:COLO-320.CNhs10737.10420-106C6 37.2 0.63
cell_line papillotubular adenocarcinoma cell line:TGBC18TKB.CNhs10734.10417-106C3 36.4 0.646
cell_line rectal cancer cell line:TT1TKB.CNhs11255.10469-106I1 35.9 0.631
cell_line rhabdomyosarcoma cell line:RMS-YM.CNhs11269.10477-106I9 35.8 0.563
cell_line acute myeloid leukemia (FAB M6) cell line:F-36E.CNhs13060.10836-111D8 35.7 0.587
cell_line gastric adenocarcinoma cell line:MKN45.CNhs11819.10612-108F9 35.6 0.682
cell_line carcinoid cell line:SK-PN-DW.CNhs11846.10719-109I8 35.6 0.67
cell_line diffuse large B-cell lymphoma cell line:CTB-1.CNhs11741.10631-108I1 35.2 0.617
cell_line carcinosarcoma cell line:JHUCS-1.CNhs11747.10642-109A3 34.9 0.617
cell_line glioblastoma cell line:T98G.CNhs11272.10485-107A8 34.9 0.653
cell_line lens epithelial cell line:SRA 01/04.CNhs11750.10647-109A8 34.7 0.636
cell_line small cell lung carcinoma cell line:LK-2.CNhs11285.10541-107H1 34.0 0.588
cell_line cervical cancer cell line:ME-180.CNhs11289.10553-107I4 33.9 0.643
cell_line acute myeloid leukemia (FAB M7) cell line:MKPL-1.CNhs11888.10802-111A1 33.8 0.578
cell_line extraskeletal myxoid chondrosarcoma cell line:H-EMC-SS.CNhs10728.10410-106B5 33.2 0.62
cell_line acute myeloid leukemia (FAB M2) cell line:NK