Gene info
HGNC approved symbolDNMT3L
HGNC approved nameDNA (cytosine-5-)-methyltransferase 3-like
Entrez gene IDGeneID:29947
(SSTAR profile)
UniProt AC (human)Q9UJW3
UniProt ID (human)DNM3L_HUMAN
Pfam domainsPfam-B_139748 PB139748 (181-229)
Pfam-B_41249 PB041249 (91-179)
MGI symbolDnmt3l
MGI IDMGI:1859287
UniProt AC (mouse)Q9CWR8
UniProt ID (mouse)DNM3L_MOUSE
HGNC gene family tag#
HGNC gene family description#
FunctionHistone modification read
PMID for information on functionPMID:17687327
Protein complex#
Target moleculehistone
Target entityH3K4
PMID for information on targetPMID:17687327
CommentDNMT3L specifically interacts with the extreme amino terminus of histone H3, this interaction is strongly inhibited by methylation at lysine 4 of histone H3.
Status of entry#

Expression statistics
Expression range: 0.0 to 488.42
Mean expression: 1.31 ± 19.18
Median expression: 0.0
Sample class Sample Expression (RLE-normalized CAGE tags per million)
Quantile over all genes
cell_line testicular germ cell embryonal carcinoma cell line:NEC15.CNhs12362.10593-108D8 488.4 0.973
cell_line choriocarcinoma cell line:T3M-3.CNhs11820.10618-108G6 206.4 0.919
cell_line testicular germ cell embryonal carcinoma cell line:ITO-II.CNhs11876.10786-110H3 152.0 0.894
cell_line testicular germ cell embryonal carcinoma cell line:NEC14.CNhs12351.10591-108D6 117.6 0.848
cell_line pancreatic carcinoma cell line:NOR-P1.CNhs11832.10698-109G5 83.5 0.834
cell_line choriocarcinoma cell line:BeWo.CNhs10740.10423-106C9 39.8 0.686
cell_line testicular germ cell embryonal carcinoma cell line:NEC8.CNhs11726.10590-108D5 37.4 0.639
cell_line retinoblastoma cell line:Y79.CNhs11267.10475-106I7 11.5 0.266
cell_line small cell lung carcinoma cell line:NCI-H82.CNhs12809.10842-111E5 11.4 0.293
cell_line teratocarcinoma cell line:NCC-IT-A3.CNhs11878.10790-110H7 5.5 0.195