Gene info
HGNC approved symbolDR1
HGNC approved namedown-regulator of transcription 1, TBP-binding (negative cofactor 2)
Entrez gene IDGeneID:1810
(SSTAR profile)
UniProt AC (human)Q01658
UniProt ID (human)NC2B_HUMAN
Pfam domainsCBFD_NFYB_HMF PF00808 (11-75)
MGI symbolDr1
MGI IDMGI:1100515
UniProt AC (mouse)Q91WV0
UniProt ID (mouse)NC2B_MOUSE
HGNC gene family tag#
HGNC gene family description#
FunctionHistone chaperone
PMID for information on functionPMID:18838386
Protein complexATAC
Target moleculehistone
Target entity#
PMID for information on targetPMID:18838386
CommentYEATS2-NC2beta=DR1 histone fold module that interacts with the TATA-binding protein (TBP) and negatively regulates transcription when recruited to a promoter.
Status of entry#

Expression statistics
Expression range: 10.22 to 141.36
Mean expression: 50.14 ± 16.94
Median expression: 48.32
Sample class Sample Expression (RLE-normalized CAGE tags per million)
Quantile over all genes
cell_line leukemia, chronic megakaryoblastic cell line:MEG-01.CNhs11859.10752-110D5 141.4 0.89
cell_line acute lymphoblastic leukemia (T-ALL) cell line:HPB-ALL.CNhs10746.10429-106D6 128.5 0.859
cell_line oral squamous cell carcinoma cell line:Ca9-22.CNhs10752.10434-106E2 115.0 0.891
cell_line acute myeloid leukemia (FAB M5) cell line:THP-1 (thawed).CNhs10724.10405-106A9 99.1 0.854
cell_line acute myeloid leukemia (FAB M5) cell line:THP-1 (revived).CNhs10723.10400-106A4 97.1 0.853
cell_line Burkitt's lymphoma cell line:DAUDI.CNhs10739.10422-106C8 94.9 0.819
cell_line cord blood derived cell line:COBL-a 24h infection(-C).CNhs11049.10452-106G2 92.2 0.825
cell_line acute