Gene info
HGNC approved symbolDTX3L
HGNC IDHGNC:30323
HGNC approved namedeltex 3 like, E3 ubiquitin ligase
Entrez gene IDGeneID:151636
(SSTAR profile)
UniProt AC (human)Q8TDB6
UniProt ID (human)DTX3L_HUMAN
Pfam domainsPfam-B_11420 PB011420 (311-389, 706-737)
zf-RING_2 PF13639 (559-600)
MGI symbolDtx3l
MGI IDMGI:2656973
UniProt AC (mouse)Q3UIR3
UniProt ID (mouse)DTX3L_MOUSE
HGNC gene family tagRNF
HGNC gene family descriptionRING-type (C3HC4) zinc fingers
FunctionHistone modification write
ModificationHistone ubiquitination
PMID for information on functionPMID:19818714
Protein complex#
Target moleculehistone
Target entityH4K91
Product#
PMID for information on targetPMID:19818714
CommentBBAP=DTX3L selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents.
Status of entry#

Expression statistics
Expression range: 0.0 to 471.36
Mean expression: 32.67 ± 48.1
Median expression: 20.47
Sample class Sample Expression (RLE-normalized CAGE tags per million)
Quantile over all genes
cell_line mesothelioma cell line:Mero-82.CNhs13069.10853-111F7 165.7 0.894
cell_line malignant trichilemmal cyst cell line:DJM-1.CNhs10730.10412-106B7 165.3 0.904
cell_line mesothelioma cell line:ACC-MESO-4.CNhs11264.10494-107B8 164.0 0.911
cell_line gall bladder carcinoma cell line:TGBC14TKB.CNhs11256.10470-106I2 163.3 0.894
cell_line myeloma cell line:PCM6.CNhs11258.10474-106I6 126.1 0.91
cell_line squamous cell carcinoma cell line:EC-GI-10.CNhs11252.10463-106H4 113.9 0.902
cell_line epidermoid carcinoma cell line:A431.CNhs10743.10426-106D3 106.6 0.863
cell_line mesothelioma cell line:NCI-H2452.CNhs13064.10848-111F2 106.1 0.878
cell_line mesodermal tumor cell line:HIRS-BM.CNhs12191.10696-109G3 104.7 0.876
cell_line meningioma cell line:HKBMM.CNhs11945.10691-109F7 100.2 0.894
cell_line bile duct carcinoma cell line:TFK-1.CNhs11265.10496-107C1 90.9 0.877
cell_line anaplastic large cell lymphoma cell line:Ki-JK.CNhs11881.10795-110I3 90.6 0.838
cell_line pharyngeal carcinoma cell line:Detroit 562.CNhs11849.10723-110A3 86.1 0.869
cell_line papillotubular adenocarcinoma cell line:TGBC18TKB.CNhs10734.10417-106C3 76.3 0.842
cell_line large cell lung carcinoma cell line:IA-LM.CNhs11277.10509-107D5 73.5 0.847
cell_line mesothelioma cell line:ONE58.CNhs13075.10858-111G3 72.9 0.849
cell_line signet ring carcinoma cell line:Kato III.CNhs10753.10436-106E4 71.0 0.831
cell_line rectal cancer cell line:TT1TKB.CNhs11255.10469-106I1 70.6 0.798
cell_line acute myeloid leukemia (FAB M7) cell line:MKPL-1.CNhs11888.10802-111A1 69.1 0.755
cell_line transitional-cell carcinoma cell line:JMSU1.CNhs11261.10492-107B6 65.9 0.801
cell_line endometrial carcinoma cell line:OMC-2.CNhs11266.10497-107C2 63.8 0.812
cell_line small cell lung carcinoma cell line:WA-hT.CNhs11812.10562-108A4 62.3 0.771
cell_line pleomorphic hepatocellular carcinoma cell line:SNU-387.CNhs11933.10706-109H4 62.3 0.793
cell_line oral squamous cell carcinoma cell line:HSC-3.CNhs11717.10545-107H5 61.3 0.81
cell_line normal intestinal epithelial cell line:FHs 74 Int.CNhs11950.10812-111B2 61.2 0.844
cell_line plasma cell leukemia cell line:ARH-77.CNhs12807.10840-111E3 61.0 0.791
cell_line b cell line:RPMI1788.CNhs10744.10427-106D4 59.9 0.771
cell_line gastric adenocarcinoma cell line:MKN1.CNhs11737.10614-108G2 59.7 0.809
cell_line bile duct carcinoma cell line:HuCCT1.CNhs10750.10432-106D9 57.2 0.8
cell_line acute lymphoblastic leukemia (B-ALL) cell line:BALL-1.CNhs11251.10455-106G5 56.9 0.754
cell_line ductal cell carcinoma cell line:KLM-1.CNhs11100.10438-106E6 56.7 0.772
cell_line glioblastoma cell line:A172, tech_rep2.CNhs11248.10444-106F3 54.4 0.771
cell_line signet ring carcinoma cell line:NUGC-4.CNhs11270.10483-107A6 53.9 0.778
cell_line glioblastoma cell line:A172, tech_rep1.CNhs11185.10444-106F3 53.7 0.768
cell_line lung adenocarcinoma cell line:PC-14.CNhs10726.10408-106B3 53.6 0.733
cell_line glassy cell carcinoma cell line:HOKUG.CNhs11824.10688-109F4 52.8 0.743
cell_line mixed mullerian tumor cell line:HTMMT.CNhs11944.10689-109F5 52.4 0.801
cell_line mesothelioma cell line:ACC-MESO-1.CNhs11263.10493-107B7 51.8 0.795
cell_line squamous cell lung carcinoma cell line:EBC-1.CNhs11273.10486-107A9 50.2 0.785
cell_line NK T cell leukemia cell line:KHYG-1.CNhs11867.10777-110G3 49.4 0.731
cell_line leukemia, chronic megakaryoblastic cell line:MEG-01.CNhs11859.10752-110D5 47.3 0.721
cell_line myxofibrosarcoma cell line:MFH-ino.CNhs11729.10600-108E6 47.1 0.719
cell_line xeroderma pigentosum b cell line:XPL 17.CNhs11813.10563-108A5 46.8 0.76
cell_line oral squamous cell carcinoma cell line:SAS.CNhs11810.10544-107H4 46.7 0.74
cell_line squamous cell carcinoma cell line:T3M-5.CNhs11739.10616-108G4 44.8 0.757
cell_line gall bladder carcinoma cell line:TGBC2TKB.CNhs10733.10415-106C1 43.8 0.758
cell_line splenic lymphoma with villous lymphocytes cell line:SLVL.CNhs10741.10424-106D1 43.6 0.692
cell_line serous adenocarcinoma cell line:JHOS-2.CNhs11746.10639-108I9 43.5 0.74
cell_line cervical cancer cell line:ME-180.CNhs11289.10553-107I4 43.1 0.708
cell_line anaplastic carcinoma cell line:8305C.CNhs10745.10428-106D5 43.0 0.762
cell_line acute myeloid leukemia (FAB M2) cell line:NKM-1.CNhs11864.10765-110E9 42.9 0.689
cell_line embryonic kidney cell line: HEK293/SLAM infection, 24hr.CNhs11047.10451-106G1 41.9 0.632
cell_line tubular adenocarcinoma cell line:SUIT-2.CNhs11883.10797-110I5 40.7 0.773
cell_line adenocarcinoma cell line:IM95m.CNhs11882.10796-110I4 40.4 0.721
cell_line sacrococcigeal teratoma cell line:HTST.CNhs11829.10695-109G2 40.1 0.719
cell_line liposarcoma cell line:SW 872.CNhs11851.10726-110A6 39.4 0.702
cell_line renal cell carcinoma cell line:OS-RC-2.CNhs10729.10411-106B6 38.2 0.722
cell_line large cell non-keratinizing squamous carcinoma cell line:SKG-II-SF.CNhs11825.10692-109F8 37.6 0.669
cell_line acute myeloid leukemia (FAB M6) cell line:F-36E.CNhs13060.10836-111D8 36.9 0.594
cell_line gastric adenocarcinoma cell line:MKN45.CNhs11819.10612-108F9 36.9 0.695
cell_line B lymphoblastoid cell line: GM12878 ENCODE, biol_rep1.CNhs12331.10821-111C2 36.8 0.608
cell_line bone marrow stromal cell line:StromaNKtert.CNhs11931.10686-109F2 36.7 0.679
cell_line oral squamous cell carcinoma cell line:Ca9-22.CNhs10752.10434-106E2 36.6 0.682
cell_line bronchioalveolar carcinoma cell line:NCI-H358.CNhs11840.10709-109H7 36.4 0.665
cell_line osteosarcoma cell line:143B/TK^(-)neo^(R).CNhs11279.10510-107D6 35.9 0.613
cell_line thyroid carcinoma cell line:TCO-1.CNhs11872.10783-110G9 35.5 0.686
cell_line serous cystadenocarcinoma cell line:HTOA.CNhs11827.10693-109F9 34.6 0.683
cell_line B lymphoblastoid cell line: GM12878 ENCODE, biol_rep3.CNhs12333.10823-111C4 34.5 0.593
cell_line giant cell carcinoma cell line:Lu99B.CNhs10751.10433-106E1 33.9 0.664
cell_line bronchogenic carcinoma cell line:ChaGo-K-1.CNhs11841.10710-109H8 33.6 0.648
cell_line mucinous cystadenocarcinoma cell line:MCAS.CNhs11873.10784-110H1 33.4 0.631
cell_line mesothelioma cell line:Mero-41.CNhs13067.10851-111F5 33.1 0.686
cell_line papillary adenocarcinoma cell line:8505C.CNhs11716.10437-106E5 32.9 0.678
cell_line acute myeloid leukemia (FAB M2) cell line:Kasumi-6.CNhs13052.10792-110H9 32.9 0.625
cell_line acantholytic squamous carcinoma cell line:HCC1806.CNhs11844.10717-109I6 32.6 0.638
cell_line acute myeloid leukemia (FAB M0) cell line:KG-1.CNhs13053.10827-111C8 32.1 0.586
cell_line myelodysplastic syndrome cell line:SKM-1.CNhs11934.10772-110F7 32.1 0.592
cell_line mesothelioma cell line:Mero-25.CNhs13066.10850-111F4 32.1 0.67
cell_line B lymphoblastoid cell line: GM12878 ENCODE, biol_rep2.CNhs12332.10822-111C3 31.2 0.572
cell_line cord blood derived cell line:COBL-a 24h infection(-C).CNhs11049.10452-106G2 31.1 0.537
cell_line acute myeloid leukemia (FAB M6) cell line:EEB.CNhs13059.10835-111D7 30.9 0.572
cell_line Ewing's sarcoma cell line:Hs 863.T.CNhs11836.1070