Gene info
HGNC approved symbolEXOSC4
HGNC approved nameexosome component 4
Entrez gene IDGeneID:54512
(SSTAR profile)
UniProt AC (human)Q9NPD3
UniProt ID (human)EXOS4_HUMAN
Pfam domainsPfam-B_25613 PB025613 (221-243)
RNase_PH PF01138 (21-152)
RNase_PH_C PF03725 (155-220)
MGI symbolExosc4
MGI IDMGI:1923576
UniProt AC (mouse)Q921I9
UniProt ID (mouse)EXOS4_MOUSE
HGNC gene family tag#
HGNC gene family description#
FunctionScaffold protein, RNA modification
ModificationRNA degradation
PMID for information on functionPMID:17174896
Protein complexRNA exosome
Target moleculeRNA
Target entity#
PMID for information on targetPMID:17174896
CommentRNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA.
Status of entry#

Expression statistics
Expression range: 0.0 to 123.87
Mean expression: 18.78 ± 12.31
Median expression: 15.43
Sample class Sample Expression (RLE-normalized CAGE tags per million)
Quantile over all genes
cell_line malignant trichilemmal cyst cell line:DJM-1.CNhs10730.10412-106B7 71.5 0.793
cell_line prostate cancer cell line:PC-3.CNhs11243.10439-106E7 58.3 0.787
cell_line non-small cell lung cancer cell line:NCI-H1385.CNhs12193.10730-110B1 53.6 0.745
cell_line Hep-2 cells mock treated, biol_rep1.CNhs13479.11898-125E8 52.1 0.758
cell_line neuroepithelioma cell line:SK-N-MC.CNhs11853.10728-110A8 52.0 0.703
cell_line squamous cell carcinoma cell line:T3M-5.CNhs11739.10616-108G4 51.9 0.801
cell_line fibrous histiocytoma cell line:GCT TIB-223.CNhs11842.10711-109H9 51.1 0.768
cell_line gastric adenocarcinoma cell line:MKN1.CNhs11737.10614-108G2 50.6 0.783
cell_line Hep-2 cells treated with Streptococci strain 5448, biol_rep1.CNhs13477.11890-125D9 50.2 0.749
cell_line osteosarcoma cell line:HS-Os-1.CNhs11290.10558-107I9 49.1 0.741
cell_line meningioma cell line:HKBMM.CNhs11945.10691-109F7 48.7 0.8
cell_line Hep-2 cells treated with Streptococci strain JRS4, biol_rep1.CNhs13478.11894-125E4 46.4 0.752
cell_line Hep-2 cells mock treated, biol_rep3.CNhs13501.11900-125F1 46.3 0.734
cell_line Hep-2 cells treated with Streptococci strain 5448, biol_rep3.CNhs13497.11892-125E2 46.0 0.733
cell_line leiomyoma cell line:15242A.CNhs11723.10570-108B3 44.9 0.837
cell_line myelodysplastic syndrome cell line:SKM-1.CNhs11934.10772-110F7 42.5 0.676
cell_line Hep-2 cells treated with Streptococci strain JRS4, biol_rep3.CNhs13499.11896-125E6 42.3 0.736
cell_line acute myeloid leukemia (FAB M6) cell line:F-36E.CNhs13060.10836-111D8 41.8 0.639
cell_line Hep-2 cells treated with Streptococci strain JRS4, biol_rep2.CNhs13498.11895-125E5 41.2 0.73
cell_line Hep-2 cells mock treated, biol_rep2.CNhs13500.11899-125E9 41.1 0.714
cell_line neuroectodermal tumor cell line:FU-RPNT-2.CNhs11753.10663-109C6 41.0 0.672
cell_line chronic myeloblastic leukemia (CML) cell line:KCL-22.CNhs11886.10801-110I9 41.0 0.702
cell_line leukemia, chronic megakaryoblastic cell line:MEG-01.CNhs11859.10752-110D5 41.0 0.678
cell_line Hep-2 cells treated with Streptococci strain 5448, biol_rep2.CNhs13496.11891-125E1 40.7 0.72
cell_line embryonic pancreas cell line:2C6.CNhs11814.10603-108E9 40.6 0.687
cell_line large cell lung carcinoma cell line:IA-LM.CNhs11277.10509-107D5 40.0 0.689
cell_line chronic lymphocytic leukemia (T-CLL) cell line:SKW-3.CNhs11714.10416-106C2 39.9 0.686
cell_line acute myeloid leukemia (FAB M0) cell line:KG-1.CNhs13053.10827-111C8 39.7 0.663
cell_line synovial sarcoma cell line:HS-SY-II.CNhs11244.10441-106E9 39.0 0.648
cell_line acute myeloid leukemia (FAB M2) cell line:Kasumi-1.CNhs13502.10788-110H5 39.0 0.692
cell_line biphenotypic B myelomonocytic leukemia cell line:MV-4-11.CNhs11845.10718-109I7 38.4 0.679
cell_line merkel cell carcinoma cell line:MS-1.CNhs12839.10844-111E7 37.8 0.624
cell_line embryonic kidney cell line: HEK293/SLAM infection, 24hr.CNhs11047.10451-106G1 37.4 0.588
cell_line rhabdomyosarcoma cell line:RMS-YM.CNhs11269.10477-106I9 37.0 0.577
cell_line acute myeloid leukemia (FAB M7) cell line:MKPL-1.CNhs11888.10802-111A1 35.2 0.589
cell_line mesothelioma cell line:Mero-82.CNhs13069.10853-111F7 35.2 0.668
cell_line leiomyoblastoma cell line:G-402.CNhs11848.10721-110A1 34.8 0.654
cell_line endometrioid adenocarcinoma cell line:JHUEM-1.CNhs11