Gene info
HGNC approved symbolHIRA
HGNC IDHGNC:4916
HGNC approved namehistone cell cycle regulator
Entrez gene IDGeneID:7290
(SSTAR profile)
UniProt AC (human)P54198
UniProt ID (human)HIRA_HUMAN
Pfam domainsHIRA_B PF09453 (448-471)
Hira PF07569 (763-962)
Pfam-B_18560 PB018560 (963-1015)
WD40 PF00400 (5-44, 60-98, 121-159, 164-202, 258-312)
MGI symbolHira
MGI IDMGI:99430
UniProt AC (mouse)Q61666
UniProt ID (mouse)HIRA_MOUSE
HGNC gene family tagWDR
HGNC gene family descriptionWD repeat domain containing
FunctionHistone modification read
Modification#
PMID for information on functionPMID:9710638
Protein complex#
Target moleculehistone
Target entityH2B, H4
Product#
PMID for information on targetPMID:9710638
CommentHIRA interacts with core histone H4. H2B- and H4-binding domains are overlapping but distinguishable in the carboxy-terminal region of HIRA, and the region for HIRA interaction has been mapped to the amino-terminal tail of H2B and the second alpha helix of H4.
Status of entry#

Expression statistics
Expression range: 11.52 to 143.92
Mean expression: 41.82 ± 15.16
Median expression: 39.95
Sample class Sample Expression (RLE-normalized CAGE tags per million)
Quantile over all genes
cell_line Hodgkin's lymphoma cell line:HD-Mar2.CNhs11715.10435-106E3 143.9 0.866
cell_line chronic myelogenous leukemia cell line:K562 ENCODE, biol_rep1.CNhs12334.10824-111C5 117.1 0.852
cell_line chronic myelogenous leukemia cell line:K562 ENCODE, biol_rep3.CNhs12336.10826-111C7 110.1 0.844
cell_line chronic myelogenous leukemia cell line:K562 ENCODE, biol_rep2.CNhs12335.10825-111C6 108.4 0.844
cell_line chronic myelogenous leukemia cell line:K562.CNhs11250.10454-106G