Gene info
HGNC approved symbolPELP1
Status of entry#
HGNC ID30134
HGNC approved nameproline, glutamate and leucine rich protein 1
Entrez gene ID27043
UniProt AC (human)Q8IZL8
UniProt ID (human)PELP1_HUMAN
Pfam domainsNUC202 PF08166 423-489 569-642, RIX1 PF08167 66-226
MGI symbolPelp1
MGI ID1922523
UniProt AC (mouse)Q9DBD5
UniProt ID (mouse)PELP1_MOUSE
HGNC gene family tag#
HGNC gene family description#
FunctionHistone modification read, Histone modification write cofactor
ModificationHistone methylation, Histone acetylation
PMID for information on function15456770, 11481323
Protein complexCHD8, MLL2/3, MLL4/WBP7
Target moleculehistone
Target entityH1, H3, H4
Product#
UniProt ID of targets#
PMID for information on target15456770, 15374949
CommentC-terminal glutamic acid-abundant region bound to the hypoacetylated histones H3 and H4 and prevents them from becoming substrates of histone acetyltransferase. Thus PELP1 promotes and maintains the hypoacetylated state of histones at the target genomic site, and ER binding reverses its role to hyperacetylate histones through an as yet unidentified mechanism.

Expression statistics
Expression range: N/A
Mean expression: N/A
Median expression: N/A
Sample class Sample Expression (RLE-normalized CAGE tags per million)
Quantile over all genes