Gene info
HGNC approved symbolCBX4
HGNC IDHGNC:1554
HGNC approved namechromobox homolog 4
Entrez gene IDGeneID:8535
(SSTAR profile)
UniProt AC (human)O00257
UniProt ID (human)CBX4_HUMAN
Pfam domainsChromo PF00385 (11-60)
Pfam-B_16393 PB016393 (481-531)
Pfam-B_26041 PB026041 (401-479)
Pfam-B_8537 PB008537 (82-281)
MGI symbolCbx4
MGI IDMGI:1195985
UniProt AC (mouse)O55187
UniProt ID (mouse)CBX4_MOUSE
HGNC gene family tag#
HGNC gene family description#
FunctionHistone modification read
Modification#
PMID for information on functionPMID:21047797
Protein complexPRC1
Target moleculehistone
Target entityH3K9me3
Product#
PMID for information on targetPMID:21047797
CommentCbx2 and Cbx7 recognizes both H3K9me3 and H3K27me3, whereas Cbx4 prefers H3K9me3.
Status of entry#

Expression statistics
Expression range: 2.08 to 604.94
Mean expression: 46.97 ± 54.11
Median expression: 32.33
Sample class Sample Expression (RLE-normalized CAGE tags per million)
Quantile over all genes
cell_line bile duct carcinoma cell line:TFK-1.CNhs11265.10496-107C1 365.4 0.956
cell_line somatostatinoma cell line:QGP-1.CNhs11869.10781-110G7 355.9 0.951
cell_line hepatoma cell line:Li-7.CNhs11271.10484-107A7 307.9 0.947
cell_line gastric adenocarcinoma cell line:MKN45.CNhs11819.10612-108F9 214.7 0.928
cell_line signet ring carcinoma cell line:Kato III.CNhs10753.10436-106E4 213.5 0.913
cell_line mesothelioma cell line:Mero-25.CNhs13066.10850-111F4 179.3 0.906
cell_line cervical cancer cell line:ME-180.CNhs11289.10553-107I4 178.2 0.923
cell_line lung adenocarcinoma cell line:A549.CNhs11275.10499-107C4 173.7 0.921
cell_line neuroblastoma cell line:CHP-134.CNhs11276.10508-107D4 170.4 0.892
cell_line squamous cell carcinoma cell line:EC-GI-10.CNhs11252.10463-106H4 165.7 0.919
cell_line anaplastic squamous cell carcinoma cell line:RPMI 2650.CNhs11889.10805-111A4 164.9 0.882
cell_line malignant trichilemmal cyst cell line:DJM-1.CNhs10730.10412-106B7 164.7 0.902
cell_line melanoma cell line:COLO 679.CNhs11281.10514-107E1 161.4 0.91
cell_line non-small cell lung cancer cell line:NCI-H1385.CNhs12193.10730-110B1 160.9 0.88
cell_line signet ring carcinoma cell line:NUGC-4.CNhs11270.10483-107A6 155.9 0.896
cell_line cord blood derived cell line:COBL-a 24h infection(-C).CNhs11049.10452-106G2 155.4 0.873
cell_line ductal cell carcinoma cell line:KLM-1.CNhs11100.10438-106E6 141.7 0.897
cell_line glassy cell carcinoma cell line:HOKUG.CNhs11824.10688-109F4 132.5 0.901
cell_line maxillary sinus tumor cell line:HSQ-89.CNhs10732.10414-106B9 130.7 0.894
cell_line oral squamous cell carcinoma cell line:HO-1-u-1.CNhs11287.10550-107I1 129.1 0.888
cell_line rectal cancer cell line:TT1TKB.CNhs11255.10469-106I1 123.6 0.886
cell_line embryonic pancreas cell line:2C6.CNhs11814.10603-108E9 120.7 0.888
cell_line rhabdomyosarcoma cell line:RMS-YM.CNhs11269.10477-106I9 120.1 0.845
cell_line melanoma cell line:G-361.CNhs11254.10465-106H6 119.6 0.905
cell_line mucinous cystadenocarcinoma cell line:MCAS.CNhs11873.10784-110H1 119.0 0.873
cell_line small cell lung carcinoma cell line:WA-hT.CNhs11812.10562-108A4 118.2 0.861
cell_line embryonic pancreas cell line:1C3IKEI.CNhs11733.10606-108F3 115.8 0.885
cell_line leukemia, chronic megakaryoblastic cell line:MEG-01.CNhs11859.10752-110D5 115.1 0.868
cell_line embryonic pancreas cell line:1B2C6.CNhs11731.10604-108F1 115.0 0.871
cell_line non T non B acute lymphoblastic leukemia (ALL) cell line:P30/OHK.CNhs10747.10430-106D7 114.3 0.828
cell_line neuroblastoma cell line:NBsusSR.CNhs11818.10607-108F4 110.6 0.869
cell_line serous cystadenocarcinoma cell line:HTOA.CNhs11827.10693-109F9 109.1 0.897
cell_line NK T cell leukemia cell line:KHYG-1.CNhs11867.10777-110G3 106.1 0.852
cell_line small cell gastrointestinal carcinoma cell line:ECC10.CNhs11736.10610-108F7 101.7 0.837
cell_line hepatoblastoma cell line:HuH-6.CNhs11742.10633-108I3 101.4 0.796
cell_line gastrointestinal carcinoma cell line:ECC12.CNhs11738.10615-108G3 97.5 0.844
cell_line embryonic kidney cell line: HEK293/SLAM infection, 24hr.CNhs11047.10451-106G1 94.9 0.829
cell_line acute myeloid leukemia (FAB M2) cell line:NKM-1.CNhs11864.10765-110E9 94.7 0.85
cell_line cervical cancer cell line:D98-AH2.CNhs11288.10552-107I3 94.6 0.856
cell_line transitional-cell carcinoma cell line:5637.CNhs10735.10418-106C4 94.3 0.848
cell_line peripheral neuroectodermal tumor cell line:KU-SN.CNhs11830.10697-109G4 93.6 0.856
cell_line synovial sarcoma cell line:HS-SY-II.CNhs11244.10441-106E9 91.2 0.835
cell_line choriocarcinoma cell line:T3M-3.CNhs11820.10618-108G6 87.4 0.831
cell_line adenocarcinoma cell line:IM95m.CNhs11882.10796-110I4 87.2 0.863
cell_line mesothelioma cell line:ACC-MESO-4.CNhs11264.10494-107B8 86.2 0.842
cell_line acute myeloid leukemia (FAB M1) cell line:HYT-1.CNhs13054.10828-111C9 86.2 0.848
cell_line oral squamous cell carcinoma cell line:Ca9-22.CNhs10752.10434-106E2 85.2 0.863
cell_line epitheloid carcinoma cell line: HelaS3 ENCODE, biol_rep2.CNhs12326.10816-111B6 84.8 0.816
cell_line acute myeloid leukemia (FAB M5) cell line:P31/FUJ.CNhs13051.10770-110F5 84.2 0.828
cell_line acute lymphoblastic leukemia (T-ALL) cell line:HPB-ALL.CNhs10746.10429-106D6 83.9 0.795
cell_line neuroectodermal tumor cell line:FU-RPNT-2.CNhs11753.10663-109C6 82.8 0.828
cell_line breast carcinoma cell line:MCF7.CNhs11943.10482-107A5 82.0 0.812
cell_line acute lymphoblastic leukemia (B-ALL) cell line:NALM-6.CNhs11282.10534-107G3 80.8 0.796
cell_line gastric cancer cell line:AZ521.CNhs11286.10549-107H9 80.6 0.83
cell_line large cell non-keratinizing squamous carcinoma cell line:SKG-II-SF.CNhs11825.10692-109F8 80.4 0.829
cell_line liposarcoma cell line:SW 872.CNhs11851.10726-110A6 78.6 0.848
cell_line cord blood derived cell line:COBL-a 24h infection.CNhs11050.10453-106G3 77.1 0.806
cell_line acantholytic squamous carcinoma cell line:HCC1806.CNhs11844.10717-109I6 76.9 0.82
cell_line glioblastoma cell line:T98G.CNhs11272.10485-107A8 76.6 0.821
cell_line neuroepithelioma cell line:SK-N-MC.CNhs11853.10728-110A8 76.0 0.785
cell_line small cell lung carcinoma cell line:LK-2.CNhs11285.10541-107H1 74.9 0.796
cell_line epidermoid carcinoma cell line:A431.CNhs10743.10426-106D3 74.7 0.805
cell_line small-cell gastrointestinal carcinoma cell line:ECC4.CNhs11734.10609-108F6 74.3 0.843
cell_line Wilms' tumor cell line:HFWT.CNhs11728.10597-108E3 74.1 0.82
cell_line myeloma cell line:PCM6.CNhs11258.10474-106I6 73.2 0.85
cell_line adult T-cell leukemia cell line:ATN-1.CNhs10738.10421-106C7 72.7 0.804
cell_line large cell lung carcinoma cell line:NCI-H460.CNhs12806.10839-111E2 71.7 0.862
cell_line glioma cell line:GI-1.CNhs10731.10413-106B8 71.7 0.845
cell_line mesothelioma cell line:Mero-95.CNhs13073.10856-111G1 71.5 0.833
cell_line Hodgkin's lymphoma cell line:HD-Mar2.CNhs11715.10435-106E3 70.6 0.753
cell_line endometrial carcinoma cell line:OMC-2.CNhs11266.10497-107C2 70.6 0.829
cell_line bronchioalveolar carcinoma cell line:NCI-H358.CNhs11840.10709-109H7 68.4 0.804
cell_line mixed mullerian tumor cell line:HTMMT.CNhs11944.10689-109F5 67.8 0.849
cell_line biphenotypic B myelomonocytic leukemia cell line:MV-4-11.CNhs11845.10718-109I7 67.5 0.805
cell_line cord blood derived cell line:COBL-a untreated.CNhs11045.10449-106F8 66.8 0.779
cell_line carcinosarcoma cell line:JHUCS-1.CNhs11747.10642-109A3 66.5 0.796
cell_line carcinoid cell line:SK-PN-DW.CNhs11846.10719-109I8 66.5 0.796
cell_line medulloblastoma cell line:D283 Med.CNhs12805.10838-111E1 65.3 0.75
cell_line bronchogenic carcinoma cell line:ChaGo-K-1.CNhs11841.10710-109H8 65.2 0.793
cell_line hepatocellular carcinoma cell line: HepG2 ENCODE, biol_rep1.CNhs12328.10818-111B8 65.0 0.773
cell_line neuroblastoma cell line:NH-12.CNhs11811.10555-107I6 63.5 0.764
cell_line hepatocellular carcinoma cell line: HepG2 ENCODE, biol_rep3.CNhs12330.10820-111C1 63.2 0.763
cell_line hepatocellular carcinoma cell line: HepG2 ENCODE, biol_rep2.CNhs12329.10819-111B9 62.9 0.772
cell_line lymphangiectasia cell line:DS-1.CNhs11852.10727-110A7 62.8 0.812
cell_line embryonic pancreas cell line:1C3D3.CNhs11732.10605-108F2 61.9 0.826
cell_line neuroectodermal tumor cell line:FU-RPNT-1.CNhs11744.10637-108I7 61.0 0.75
cell_line colon carcinoma cell line:CACO-2.CNhs11280.10513-107D9 60.6 0.