Protein complex info
Complex group nameISWI
Complex nameACF
Status of entryUpdated
Genes in complexBAZ1A#62, SMARCA5#562
Alternative namesACF1-ISWI, ACF/WCRF
Proteins involvedBAZ1A, SMARCA5/SNF2H(ISWI-type ATPase)
Uniprot IDs of involved proteins
BAZ1A_HUMAN, SMCA5_HUMAN
PMID for reference on complex composition10655480, 25486562
Functionchromatin remodeling complex
PMID for reference on function12434153, 14759371, 17099699
Target molecule typechromatin
Specific targetpericentromeric chromatin
Product#
Target UniProt ID#
PMID for reference on targets and products12434153
CommentUnfolding heterochromatin for replication. ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.