Protein complex info
Complex group nameSWI/SNF
Complex namenpBAF
Status of entryUpdated
Genes in complexACTL6A#4, ACTB#3, (ARID1A#30|ARID1B#31), SMARCA2#560, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, SMARCD1#568, SMARCD3#570, SMARCB1#565, PHF10#433
Alternative namesneural progenitors-specific chromatin remodeling complex, BAF53
Proteins involvedARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin
Uniprot IDs of involved proteins
ACL6A_HUMAN, ACTB_HUMAN, (ARI1A_HUMAN|ARI1B_HUMAN), SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD3_HUMAN, SNF5_HUMAN, PHF10_HUMAN
PMID for reference on complex composition10078207, 11078522, 18765789, by similarity
Functionchromatin remodeling complex
PMID for reference on function11078522
Target molecule typechromatin
Specific target#
Product#
Target UniProt ID#
PMID for reference on targets and products#
CommentNeural progenitors-specific chromatin remodeling complex. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.