Protein complex info
Complex group nameISWI
Complex nameB-WICH
Status of entryUpdated
Genes in complexBAZ1B#63, DDX21#159, DEK#161, ERCC6#198, MYBBP1A#377, MYO1C#378, SF3B1#546, SIRT7#557, SMARCA5#562
Alternative namesWICH, WSTF-SNF2h, WSTF-ISWI
Proteins involvedBAZ1B/WSTF, DDX21, DEK, ERCC6, MYBBP1A, MYO1C, SF3B1, SIRT7, SMARCA5/SNF2H(ISWI-type ATPase)
Uniprot IDs of involved proteins
BAZ1B_HUMAN, DDX21_HUMAN, DEK_HUMAN, ERCC6_HUMAN, MBB1A_HUMAN, MYO1C_HUMAN, SF3B1_HUMAN, SIR7_HUMAN, SMCA5_HUMAN
PMID for reference on complex composition16603771
Functionhistone phosphorylation complex, chromatin remodeling complex
PMID for reference on function19092802, 15753658
Target molecule typechromatin, histone
Specific targetH2AXY142
ProductH2AXY142ph
Target UniProt IDH2AX_HUMAN
PMID for reference on targets and products19092802
CommentA chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress.