Protein complex info
Complex group nameAPOB mRNA editosome
Complex nameAPOB_mRNA_editosome
Status of entry#
Genes in complexAPOBEC1#21, APOBEC3F#27, APOBEC3G#28, APOBEC3H#29, A1CF#2, AICDA#12, SYNCRIP#601
Alternative namesAppoprotein B, APOBEC1, apolipoprotein B mRNA editing enzyme complex
Proteins involvedA1CF, APOBEC3F, APOBEC3G, APOBEC3H, APOBEC1, AICDA, SYNCRIP
Uniprot IDs of involved proteins
ABEC1_HUMAN, ABC3F_HUMAN, ABC3G_HUMAN, ABC3H_HUMAN, A1CF_HUMAN, AICDA_HUMAN, HNRPQ_HUMAN
PMID for reference on complex composition17121840
FunctionmRNA editing complex
PMID for reference on function11727199
Target molecule typemRNA, DNA
Specific targetdC, mC
ProductdU, T
Target UniProt ID#
PMID for reference on targets and products11727199
CommentResponsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.