Protein complex info
Complex group nameHAT
Complex nameNuA4
Status of entry#
Genes in complexACTL6A#4, ACTB#3, BRD8#78, DMAP1#162, MEAF6#353, EP400#194, EPC1#195, ING3#279, KAT5#300, MORF4L1#362, MORF4L2#363, MRGBP#366, RUVBL1#518, RUVBL2#519, TRRAP#649, VPS72#684, YEATS4#695
Alternative names#
Proteins involvedKAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6
Uniprot IDs of involved proteins
ACL6A_HUMAN, ACTB_HUMAN, BRD8_HUMAN, DMAP1_HUMAN, EAF6_HUMAN, EP400_HUMAN, EPC1_HUMAN, ING3_HUMAN, KAT5_HUMAN, MO4L1_HUMAN, MO4L2_HUMAN, MRGBP_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, TRRAP_HUMAN, VPS72_HUMAN, YETS4_HUMAN
PMID for reference on complex composition14966270, 16387653
Functionhistone acetylation complex
PMID for reference on function14966270
Target molecule typehistone
Specific targetH4, H2A
ProductH4ac, H2Aac
Target UniProt IDH2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN, H4_HUMAN
PMID for reference on targets and products14966270
CommentIs involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.