Protein complex info
Complex group namePcG and PcG-like
Complex namePRC1
Genes in complex(CBX2#94|CBX4#96|CBX6#98|CBX7#99|CBX8#100), (BMI1#68|PCGF1#421|PCGF2#422|PCGF3#423|PCGF5#424|PCGF6#425), PHC2#430, (RING1#505|RNF2#509), (SCMH1#529|SCML2#530)
Alternative namesPRC1.2, PRC1.4
Proteins involved#
Uniprot IDs of involved proteins
(CBX2_HUMAN|CBX4_HUMAN|CBX6_HUMAN|CBX7_HUMAN|CBX8_HUMAN), (BMI1_HUMAN|PCGF1_HUMAN|PCGF2_HUMAN|PCGF3_HUMAN|PCGF5_HUMAN|PCGF6_HUMAN), (PHC1_HUMAN, PHC2_HUMAN, PHC3_HUMAN), (RING1_HUMAN|RING2_HUMAN), (SCMH1_HUMAN| SCML2_HUMAN)
PMID for reference on complex compositionPMID:12167701, PMID:22325352, PMID:24217316
FunctionPolycomb group complex
PMID for reference on functionPMID:23418308
Target molecule typehistone
Specific targetH2AK119
ProductH2AK119ub1
Target UniProt IDH2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN
PMID for reference on targets and productsPMID:23418308
CommentA complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. May modulate the levels of histone .H3K4Me3 by activating KDM5D histone demethylase.
Status of entryUpdated