Protein complex info
Complex group namePcG and PcG-like
Complex namePRC1
Status of entryUpdated
Genes in complex(CBX2#94|CBX4#96|CBX6#98|CBX7#99|CBX8#100), (BMI1#68|PCGF1#421|PCGF2#422|PCGF3#423|PCGF5#424|PCGF6#425), PHC2#430, (RING1#505|RNF2#509), (SCMH1#529|SCML2#530)
Alternative namesPRC1.2, PRC1.4
Proteins involved#
Uniprot IDs of involved proteins
(CBX2_HUMAN|CBX4_HUMAN|CBX6_HUMAN|CBX7_HUMAN|CBX8_HUMAN), (BMI1_HUMAN|PCGF1_HUMAN|PCGF2_HUMAN|PCGF3_HUMAN|PCGF5_HUMAN|PCGF6_HUMAN), (PHC1_HUMAN, PHC2_HUMAN, PHC3_HUMAN), (RING1_HUMAN|RING2_HUMAN), (SCMH1_HUMAN| SCML2_HUMAN)
PMID for reference on complex composition12167701, 22325352, 24217316
FunctionPolycomb group complex
PMID for reference on function23418308
Target molecule typehistone
Specific targetH2AK119
ProductH2AK119ub1
Target UniProt IDH2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN
PMID for reference on targets and products23418308
CommentA complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. May modulate the levels of histone .H3K4Me3 by activating KDM5D histone demethylase.