Protein complex info
Complex group namePcG and PcG-like
Complex nameBCOR
Status of entryUpdated
Genes in complex(BCOR#66|BCORL1#67), KDM2B#308, PCGF1#421, (RING1#505|RNF2#509), (RYBP#520|YAF2#693), SKP1#558, USP7#681
Alternative namesPRC1.1, RING2-KDM2B
Proteins involvedBCOR/BCORL1, RYBP/YAF2, PCGF1, RING1 or RNF2/RING2, KDM2B, USP7 and SKP1
Uniprot IDs of involved proteins
(BCOR_HUMAN|BCORL_HUMAN), KDM2B_HUMAN, PCGF1_HUMAN, (RING1_HUMAN|RING2_HUMAN), (RYBP_HUMAN|YAF2_HUMAN), SKP1_HUMAN, UBP7_HUMAN
PMID for reference on complex composition16943429, 22325352, 24217316
FunctionPolycomb like complex
PMID for reference on function16943429
Target molecule typehistone
Specific targetH2AK119
ProductH2AK119ub1
Target UniProt IDH2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN
PMID for reference on targets and products#
CommentA complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A.