Protein complex info
Complex group nameMLL
Complex nameCHD8
Status of entryUpdated
Genes in complexASH2L#40, C17orf49#91?, CHD8#129, DPY30#176, E2F6#180?, HCFC1#239?, HCFC2#240?, (HSPA1A#271|HSPA1B#272)?, INO80C#284?, KANSL1#295?, KAT8#304?, KDM6A#320?, KMT2A#325, LAS1L#334?, MAX#341?, MCRS1#351?, MEN1#355?, MGA#356?, NCOA6#391?, PAGR1#412?, PAXIP1#418?, PELP1#428?, PHF20#439?, PRPF31#485?, RBBP5#498, RNF2#509?, RUVBL1#518?, RUVBL2#519?, SENP3#533?, TAF1#606?, TAF4#612?, TAF6#615?, TAF7#617?, TAF9#619?, TEX10#629?, WDR5#687
Alternative namesMLL1/MLL, CHD8
Proteins involvedASH2L, RBBP5, WDR5, DPY30, MLL and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin
Uniprot IDs of involved proteins
ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, KMT2A_HUMAN, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, NCOA6_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?, RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN
PMID for reference on complex composition15960975, 22108599
Functionhistone methylation complex, histone acetylation complex
PMID for reference on function19556245
Target molecule typehistone
Specific targetH3K4, H4K16
ProductH3K4me, H4K16ac
Target UniProt IDH31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN
PMID for reference on targets and products19556245
CommentA multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).