Protein complex info
Complex group nameMLL
Complex nameMLL2/3
Status of entry#
Genes in complexASH2L#40, C17orf49#91?, CHD8#129?, DPY30#176, E2F6#180?, HCFC1#239?, HCFC2#240?, (HSPA1A#271|HSPA1B#272)?, INO80C#284?, KANSL1#295?, KAT8#304?, KDM6A#320?, (KMT2B#326|KMT2C#327)+, LAS1L#334?, MAX#341?, MCRS1#351?, MEN1#355?, MGA#356?, NCOA6#391?, PAGR1#412?, PAXIP1#418?, PELP1#428?, PHF20#439?, PRPF31#485?, RBBP5#498, RNF2#509?, RUVBL1#518?, RUVBL2#519?, SENP3#533?, TAF1#606?, TAF4#612?, TAF6#615?, TAF7#617?, TAF9#619?, TEX10#629?, WDR5#687
Alternative namesASCOM
Proteins involvedASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (MLL2/ALR and MLL3), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin
Uniprot IDs of involved proteins
ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN?, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, (KMT2B_HUMAN|KMT2C_HUMAN)+, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, NCOA6_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?, RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN
PMID for reference on complex composition17500065
Functionhistone methylation complex, histone acetylation complex
PMID for reference on function17500065
Target molecule typehistone
Specific targetH3K4
ProductH3K4me3
Target UniProt ID#
PMID for reference on targets and products21330447
Comment#