Protein complex info
Complex group nameSRCAP
Complex nameSRCAP
Status of entry#
Genes in complexACTL6A#4, ACTR6#8, DMAP1#162, SRCAP#584, RUVBL1#518, RUVBL2#519, YEATS4#695, ZNHIT1#718
Alternative names#
Proteins involvedSRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1
Uniprot IDs of involved proteins
ACL6A_HUMAN, ARP6_HUMAN, DMAP1_HUMAN, SRCAP_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, YETS4_HUMAN, ZNHI1_HUMAN
PMID for reference on complex composition15647280
Functionchromatin remodeling complex
PMID for reference on function15647280
Target molecule typechromatin, histone
Specific targethistone dimers containing H2B and H2A.Z
Productmononucleosomes reconstituted with recombinant H2A,H2B,H3,H4
Target UniProt IDH2AZ_HUMAN, H2B1A_HUMAN, H2B1B_HUMAN, H2B1C_HUMAN, H2B1D_HUMAN, H2B1H_HUMAN, H2B1J_HUMAN, H2B1K_HUMAN, H2B1L_HUMAN, H2B1M_HUMAN, H2B1N_HUMAN, H2B1O_HUMAN, H2B2C_HUMAN, H2B2D_HUMAN, H2B2E_HUMAN, H2B2F_HUMAN, H2B3B_HUMAN, H2BFM_HUMAN, H2BFS_HUMAN, H2BWT_HUMAN
PMID for reference on targets and products16634648, 17617668
CommentMediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. SRCAP-containing complex supports ATP-dependent exchange of histone dimers containing H2B and H2A.Z into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4.