Protein complex info
Complex group nameSRCAP
Complex nameSRCAP
Genes in complexACTL6A#4, ACTR6#8, DMAP1#162, SRCAP#584, RUVBL1#518, RUVBL2#519, YEATS4#695, ZNHIT1#718
Alternative names#
Proteins involvedSRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1
Uniprot IDs of involved proteins
ACL6A_HUMAN, ARP6_HUMAN, DMAP1_HUMAN, SRCAP_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, YETS4_HUMAN, ZNHI1_HUMAN
PMID for reference on complex compositionPMID:15647280
Functionchromatin remodeling complex
PMID for reference on functionPMID:15647280
Target molecule typechromatin, histone
Specific targethistone dimers containing H2B and H2A.Z
Productmononucleosomes reconstituted with recombinant H2A,H2B,H3,H4
Target UniProt IDH2AZ_HUMAN, H2B1A_HUMAN, H2B1B_HUMAN, H2B1C_HUMAN, H2B1D_HUMAN, H2B1H_HUMAN, H2B1J_HUMAN, H2B1K_HUMAN, H2B1L_HUMAN, H2B1M_HUMAN, H2B1N_HUMAN, H2B1O_HUMAN, H2B2C_HUMAN, H2B2D_HUMAN, H2B2E_HUMAN, H2B2F_HUMAN, H2B3B_HUMAN, H2BFM_HUMAN, H2BFS_HUMAN, H2BWT_HUMAN
PMID for reference on targets and productsPMID:16634648, PMID:17617668
CommentMediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. SRCAP-containing complex supports ATP-dependent exchange of histone dimers containing H2B and H2A.Z into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4.
Status of entry#