Protein complex info
Complex group nameDUB
Complex nameBRCA1-A
Status of entry#
Genes in complexBABAM1#57, BARD1#61, BRCA1#70, BRCC3#72, BRE#81, FAM175A#214, UIMC1#668
Alternative names#
Proteins involvedBRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1
Uniprot IDs of involved proteins
BABA1_HUMAN, BARD1_HUMAN, BRCA1_HUMAN, BRCC3_HUMAN, BRE_HUMAN, F175A_HUMAN, UIMC1_HUMAN
PMID for reference on complex composition19261746, 19261748, 19261749
Functionhistone deubiquitination complex
PMID for reference on function19261746, 19261748, 19261749
Target molecule typehistone
Specific targetH2AK63ub, H2AXK63ub
ProductH2AK63, H2AXK63
Target UniProt IDH2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN
PMID for reference on targets and products19261746, 19261748, 19261749
CommentA complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.