Protein complex info
Complex group nameCAF-1
Complex nameCAF-1
Status of entry#
Genes in complexCHAF1A#119, CHAF1B#120, RBBP4#497
Alternative names#
Proteins involvedRBBP4, CHAF1B and CHAF1A
Uniprot IDs of involved proteins
CAF1A_HUMAN, CAF1B_HUMAN, RBBP4_HUMAN
PMID for reference on complex composition8858152
Functionchromatin assembly complex
PMID for reference on function8858152
Target molecule typehistone
Specific targetH3, H4
Product#
Target UniProt IDH31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN
PMID for reference on targets and products8858152
CommentComplex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.