Protein complex info
Complex group nameCAF-1
Complex nameCAF-1
Genes in complexCHAF1A#119, CHAF1B#120, RBBP4#497
Alternative names#
Proteins involvedRBBP4, CHAF1B and CHAF1A
Uniprot IDs of involved proteins
CAF1A_HUMAN, CAF1B_HUMAN, RBBP4_HUMAN
PMID for reference on complex compositionPMID:8858152
Functionchromatin assembly complex
PMID for reference on functionPMID:8858152
Target molecule typehistone
Specific targetH3, H4
Product#
Target UniProt IDH31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN
PMID for reference on targets and productsPMID:8858152
CommentComplex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
Status of entry#