Gene info
HGNC approved symbolCBX5
HGNC IDHGNC:1555
HGNC approved namechromobox homolog 5
Entrez gene IDGeneID:23468
(SSTAR profile)
UniProt AC (human)P45973
UniProt ID (human)CBX5_HUMAN
Pfam domainsChromo PF00385 (20-69)
Chromo_shadow PF01393 (119-176)
MGI symbolCbx5
MGI IDMGI:109372
UniProt AC (mouse)Q61686
UniProt ID (mouse)CBX5_MOUSE
HGNC gene family tag#
HGNC gene family description#
FunctionHistone modification read
Modification#
PMID for information on functionPMID:21047797
Protein complex#
Target moleculehistone
Target entityH3K9me, H3K27me3
Product#
PMID for information on targetPMID:21047797
CommentExcluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph).
Status of entry#

Expression statistics
Expression range: 0.0 to 300.56
Mean expression: 69.51 ± 45.03
Median expression: 58.73
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Sample class Sample Expression (RLE-normalized CAGE tags per million)
Quantile over all genes
cell_line hepatoblastoma cell line:HuH-6.CNhs11742.10633-108I3 300.6 0.92
cell_line medulloblastoma cell line:D283 Med.CNhs12805.10838-111E1 286.5 0.911
cell_line rhabdomyosarcoma cell line:RMS-YM.CNhs11269.10477-106I9 263.9 0.9
cell_line acute myeloid leukemia (FAB M6) cell line:F-36E.CNhs13060.10836-111D8 252.3 0.907
cell_line tridermal teratoma cell line:HGRT.CNhs11828.10694-109G1 251.0 0.92
cell_line neuroepithelioma cell line:SK-N-MC.CNhs11853.10728-110A8 235.2 0.913
cell_line non T non B acute lymphoblastic leukemia (ALL) cell line:P30/OHK.CNhs10747.10430-106D7 234.3 0.891
cell_line small cell lung carcinoma cell line:LK-2.CNhs11285.10541-107H1 226.0 0.905
cell_line merkel cell carcinoma cell line:MKL-1.CNhs12838.10843-111E6 225.7 0.896
cell_line neuroectodermal tumor cell line:FU-RPNT-1.CNhs11744.10637-108I7 214.3 0.902
cell_line acute lymphoblastic leukemia (B-ALL) cell line:BALL-1.CNhs11251.10455-106G5 201.8 0.89
cell_line acute lymphoblastic leukemia (T-ALL) cell line:HPB-ALL.CNhs10746.10429-106D6 201.0 0.895
cell_line neuroblastoma cell line:CHP-134.CNhs11276.10508-107D4 198.4 0.902
cell_line acute myeloid leukemia (FAB M7) cell line:M-MOK.CNhs13049.10699-109G6 197.5 0.894
cell_line lens epithelial cell line:SRA 01/04.CNhs11750.10647-109A8 195.2 0.913
cell_line gastrointestinal carcinoma cell line:ECC12.CNhs11738.10615-108G3 195.1 0.904
cell_line myxofibrosarcoma cell line:MFH-ino.CNhs11729.10600-108E6 191.3 0.895
cell_line Burkitt's lymphoma cell line:DAUDI.CNhs10739.10422-106C8 189.5 0.888
cell_line retinoblastoma cell line:Y79.CNhs11267.10475-106I7 185.8 0.881
cell_line carcinosarcoma cell line:JHUCS-1.CNhs11747.10642-109A3 182.1 0.904
cell_line acute lymphoblastic leukemia (B-ALL) cell line:NALM-6.CNhs11282.10534-107G3 181.3 0.882
cell_line neuroectodermal tumor cell line:FU-RPNT-2.CNhs11753.10663-109C6 179.5 0.891
cell_line diffuse large B-cell lymphoma cell line:CTB-1.CNhs11741.10631-108I1 179.4 0.886
cell_line anaplastic squamous cell carcinoma cell line:RPMI 2650.CNhs11889.10805-111A4 170.8 0.885
cell_line embryonic pancreas cell line:1B2C6.CNhs11731.10604-108F1 168.8 0.905
cell_line small cell cervical cancer cell line:HCSC-1.CNhs11885.10800-110I8 165.4 0.885
cell_line small cell lung carcinoma cell line:NCI-H82.CNhs12809.10842-111E5 163.9 0.877
cell_line merkel cell carcinoma cell line:MS-1.CNhs12839.10844-111E7 162.9 0.89
cell_line Hodgkin's lymphoma cell line:HD-Mar2.CNhs11715.10435-106E3 161.6 0.871
cell_line mesenchymal stem cell line:Hu5/E18.CNhs11718.10568-108B1 159.6 0.886
cell_line acute myeloid leukemia (FAB M5) cell line:THP-1 (thawed).CNhs10724.10405-106A9 157.2 0.881
cell_line acute myeloid leukemia (FAB M6) cell line:EEB.CNhs13059.10835-111D7 156.5 0.872
cell_line acute myeloid leukemia (FAB M5) cell line:THP-1 (revived).CNhs10723.10400-106A4 155.7 0.886
cell_line neuroblastoma cell line:NB-1.CNhs11284.10539-107G8 155.5 0.887
cell_line acute myeloid leukemia (FAB M5) cell line:THP-1 (fresh).CNhs10722.10399-106A3 154.5 0.886
cell_line hereditary spherocytic anemia cell line:WIL2-NS.CNhs11891.10808-111A7 154.5 0.88
cell_line bone marrow stromal cell line:StromaNKtert.CNhs11931.10686-109F2 153.4 0.905
cell_line ductal cell carcinoma cell line:KLM-1.CNhs11100.10438-106E6 151.6 0.905
cell_line non-small cell lung cancer cell line:NCI-H1385.CNhs12193.10730-110B1 151.3 0.873
cell_line small cell gastrointestinal carcinoma cell line:ECC10.CNhs11736.10610-108F7 151.0 0.885
cell_line embryonic pancreas cell line:2C6.CNhs11814.10603-108E9 149.3 0.905
cell_line colon carcinoma cell line:COLO-320.CNhs10737.10420-106C6 148.7 0.88
cell_line acute lymphoblastic leukemia (T-ALL) cell line:Jurkat.CNhs11253.10464-106H5 145.4 0.873
cell_line embryonic pancreas cell line:1C3IKEI.CNhs11733.10606-108F3 144.7 0.906
cell_line synovial sarcoma cell line:HS-SY-II.CNhs11244.10441-106E9 144.2 0.88
cell_line neuroblastoma cell line:NH-12.CNhs11811.10555-107I6 135.9 0.868
cell_line carcinoid cell line:SK-PN-DW.CNhs11846.10719-109I8 134.4 0.876
cell_line lymphoma, malignant, hairy B-cell cell line:MLMA.CNhs11935.10775-110G1 133.6 0.859
cell_line cervical cancer cell line:ME-180.CNhs11289.10553-107I4 133.6 0.892
cell_line testicular germ cell embryonal carcinoma cell line:NEC15.CNhs12362.10593-108D8 132.9 0.875
cell_line acute myeloid leukemia (FAB M5) cell line:NOMO-1.CNhs13050.10764-110E8 132.4 0.875
cell_line large cell non-keratinizing squamous carcinoma cell line:SKG-II-SF.CNhs11825.10692-109F8 132.2 0.894
cell_line glassy cell carcinoma cell line:HOKUG.CNhs11824.10688-109F4 130.8 0.9
cell_line acute myeloid leukemia (FAB M4) cell line:FKH-1.CNhs13503.10830-111D2 130.3 0.864
cell_line small cell lung carcinoma cell line:WA-hT.CNhs11812.10562-108A4 129.4 0.872
cell_line leiomyoblastoma cell line:G-402.CNhs11848.10721-110A1 129.2 0.877
cell_line mesothelioma cell line:Mero-41.CNhs13067.10851-111F5 127.9 0.892
cell_line cervical cancer cell line:D98-AH2.CNhs11288.10552-107I3 127.7 0.887
cell_line b cell line:RPMI1788.CNhs10744.10427-106D4 126.5 0.873
cell_line teratocarcinoma cell line:PA-1.CNhs11890.10807-111A6 123.1 0.867
cell_line renal cell carcinoma cell line:OS-RC-2.CNhs10729.10411-106B6 123.1 0.897
cell_line acute myeloid leukemia (FAB M7) cell line:MKPL-1.CNhs11888.10802-111A1 122.7 0.853
cell_line teratocarcinoma cell line:NCR-G1.CNhs11884.10798-110I6 120.1 0.872
cell_line mesodermal tumor cell line:HIRS-BM.CNhs12191.10696-109G3 118.6 0.888
cell_line adult T-cell leukemia cell line:ATN-1.CNhs10738.10421-106C7 117.7 0.876
cell_line glioblastoma cell line:T98G.CNhs11272.10485-107A8 117.6 0.864
cell_line giant cell carcinoma cell line:LU65.CNhs11274.10487-107B1 117.5 0.899
cell_line gall bladder carcinoma cell line:TGBC14TKB.CNhs11256.10470-106I2 117.5 0.866
cell_line testicular germ cell embryonal carcinoma cell line:NEC8.CNhs11726.10590-108D5 116.3 0.857
cell_line bronchioalveolar carcinoma cell line:NCI-H358.CNhs11840.10709-109H7 116.2 0.869
cell_line breast carcinoma cell line:MDA-MB-453.CNhs10736.10419-106C5 116.1 0.883
cell_line mesothelioma cell line:NCI-H226.CNhs13062.10846-111E9 115.9 0.877
cell_line testicular germ cell embryonal carcinoma cell line:ITO-II.CNhs11876.10786-110H3 115.9 0.868
cell_line Wilms' tumor cell line:G-401.CNhs11892.10809-111A8 115.6 0.867
cell_line neuroblastoma cell line:NBsusSR.CNhs11818.10607-108F4 113.7 0.878
cell_line osteosarcoma cell line:143B/TK^(-)neo^(R).CNhs11279.10510-107D6 109.8 0.859
cell_line Burkitt's lymphoma cell line:RAJI.CNhs11268.10476-106I8 109.3 0.857
cell_line mesothelioma cell line:Mero-25.CNhs13066.10850-111F4 108.8 0.866
cell_line mesothelioma cell line:NCI-H28.CNhs13061.10845-111E8 108.4 0.881
cell_line glioma cell line:GI-1.CNhs10731.10413-106B8 108.4 0.894
cell_line mesothelioma cell line:ACC-MESO-4.CNhs11264.10494-107B8 107.2 0.875
cell_line pleomorphic hepatocellular carcinoma cell line:SNU-387.CNhs11933.10706-109H4 106.8 0.877
cell_line transitional-cell carcinoma cell line:JMSU1.CNhs11261.10492-107B6 105.7 0.863
cell_line clear cell carcinoma cell line:TEN.CNhs11930.10636-108I6 105.4 0.863
cell_line epidermoid carcinoma cell line:A431.CNhs10743.10426-106D3 105.3 0.861
cell_line osteosarcoma cell line:HS-Os-1.CNhs11290.10558-107I9 104.6 0.875
cell_line breast carcinoma cell line:MCF7.CNhs11943.10482-107A5 103.9 0.844
cell_line acute myeloid leukemia (FAB M2) cell line:Kasumi-6.CNhs13052.10792-110H9 103.9 0.859
cell_line rhabdomyosarcoma cell line:KYM-1.CNhs11877.10787-110H4 103.7 0.843
cell_line granulosa cell tumor cell line:KGN.CNhs11740.10624-108H3 102.3 0.886
cell_line glioblastoma cell line:A172, tech_rep2.CNhs11248.10444-106F3 101.4 0.876
cell_line small-cell gastrointestinal carcinoma cell line:ECC4.CNhs11734.10609-108F6 99.2 0.873
cell_line chronic myelogenous leukemia cell line:K562 ENCODE, biol_rep2.CNhs12335.10825-111C6 98.6 0.828
cell_line chronic myelogenous leukemia cell line:K562 ENCODE, biol_rep1.CNhs12334.10824-111C5 95.7 0.824
cell_line Hep-2 cells treated with Streptococci strain 5448, biol_rep2.CNhs13496.11891-125E1 95.6 0.849
cell_line chronic lymphocytic leukemia (T-CLL) cell line:SKW-3.CNhs11714.10416-106C2 95.0 0.833
cell_line endometrial stromal sarcoma cell line:OMC-9.CNhs11249.10448-106F7 94.9 0.883
cell_line Hep-2 cells mock treated, biol_rep3.CNhs13501.11900-125F1 94.7 0.842
cell_line NK T cell leukemia cell line:KHYG-1.CNhs11867.10777-110G3 94.2 0.84
cell_line signet ring carcinoma cell line:NUGC-4.CNhs11270.10483-107A6 93.9 0.858
cell_line acute myeloid leukemia (FAB M6) cell line:F-36P.CNhs13505.10837-111D9 93.8 0.834
cell_line carcinoid cell line:NCI-H1770.CNhs11834.10703-109H1 93.4 0.845
cell_line glioblastoma cell line:A172, tech_rep1.CNhs11185.10444-106F3 93.4 0.867
cell_line Wilms' tumor cell line:HFWT.CNhs11728.10597-108E3 93.4 0.858
cell_line Hep-2 cells mock treated, biol_rep1.CNhs13479.11898-125E8 93.3 0.84
cell_line Hep-2 cells treated with Streptococci strain JRS4, biol_rep2.CNhs13498.11895-125E5 93.2 0.854
cell_line bronchogenic carcinoma cell line:ChaGo-K-1.CNhs11841.10710-109H8 92.9 0.84
cell_line signet ring carcinoma cell line:Kato III.CNhs10753.10436-106E4 91.8 0.853
cell_line gastric cancer cell line:AZ521.CNhs11286.10549-107H9 91.5 0.852
cell_line papillotubular adenocarcinoma cell line:TGBC18TKB.CNhs10734.10417-106C3 91.2 0.868
cell_line schwannoma cell line:HS-PSS, tech_rep2.CNhs11245.10442-106F1 90.3 0.875
cell_line plasma cell leukemia cell line:ARH-77.CNhs12807.10840-111E3 90.1 0.842
cell_line acute myeloid leukemia (FAB M2) cell line:NKM-1.CNhs11864.10765-110E9 88.3 0.84
cell_line splenic lymphoma with villous lymphocytes cell line:SLVL.CNhs10741.10424-106D1 87.4 0.843
cell_line lung adenocarcinoma cell line:PC-14.CNhs10726.10408-106B3 87.4 0.838
cell_line transitional-cell carcinoma cell line:5637.CNhs10735.10418-106C4 87.3 0.837
cell_line mesothelioma cell line:NCI-H2452.CNhs13064.10848-111F2 87.2 0.85
cell_line spindle cell sarcoma cell line:Hs 132.T.CNhs11857.10737-110B8 87.2 0.876
cell_line Hep-2 cells treated with Streptococci strain 5448, biol_rep3.CNhs13497.11892-125E2 86.4 0.83
cell_line extraskeletal myxoid chondrosarcoma cell line:H-EMC-SS.CNhs10728.10410-106B5 86.0 0.857
cell_line liposarcoma cell line:SW 872.CNhs11851.10726-110A6 85.8 0.859
cell_line mixed mullerian tumor cell line:HTMMT.CNhs11944.10689-109F5 85.5 0.876
cell_line schwannoma cell line:HS-PSS, tech_rep1.CNhs11183.10442-106F1 85.2 0.864
cell_line B lymphoblastoid cell line: GM12878 ENCODE, biol_rep1.CNhs12331.10821-111C2 85.0 0.816
cell_line mesothelioma cell line:Mero-84.CNhs13072.10855-111F9 84.9 0.859
cell_line endometrial carcinoma cell line:OMC-2.CNhs11266.10497-107C2 84.8 0.858
cell_line embryonic pancreas cell line:1C3D3.CNhs11732.10605-108F2 84.7 0.869
cell_line B lymphoblastoid cell line: GM12878 ENCODE, biol_rep3.CNhs12333.10823-111C4 84.5 0.814
cell_line acute myeloid leukemia (FAB M0) cell line:Kasumi-3.CNhs13241.10789-110H6 83.1 0.83
cell_line Hep-2 cells treated with Streptococci strain 5448, biol_rep1.CNhs13477.11890-125D9 83.1 0.826
cell_line B lymphoblastoid cell line: GM12878 ENCODE, biol_rep2.CNhs12332.10822-111C3 83.0 0.815