Complex group name Complex name Status of entry Genes in complex Alternative names Proteins involved Uniprot IDs of involved proteins
PMID for reference on complex composition Function PMID for reference on function Target molecule type Specific target Product Target UniProt ID PMID for reference on targets and products Comment
ISWI ACF
(details)
Updated BAZ1A#62, SMARCA5#562 ACF1-ISWI, ACF/WCRF BAZ1A, SMARCA5/SNF2H(ISWI-type ATPase) BAZ1A_HUMAN, SMCA5_HUMAN 10655480, 25486562 chromatin remodeling complex 12434153, 14759371, 17099699 chromatin pericentromeric chromatin # # 12434153 Unfolding heterochromatin for replication. ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.
ISWI B-WICH
(details)
Updated BAZ1B#63, DDX21#159, DEK#161, ERCC6#198, MYBBP1A#377, MYO1C#378, SF3B1#546, SIRT7#557, SMARCA5#562 WICH, WSTF-SNF2h, WSTF-ISWI BAZ1B/WSTF, DDX21, DEK, ERCC6, MYBBP1A, MYO1C, SF3B1, SIRT7, SMARCA5/SNF2H(ISWI-type ATPase) BAZ1B_HUMAN, DDX21_HUMAN, DEK_HUMAN, ERCC6_HUMAN, MBB1A_HUMAN, MYO1C_HUMAN, SF3B1_HUMAN, SIR7_HUMAN, SMCA5_HUMAN 16603771 histone phosphorylation complex, chromatin remodeling complex 19092802, 15753658 chromatin, histone H2AXY142 H2AXY142ph H2AX_HUMAN 19092802 A chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress.
ISWI RSF
(details)
Updated RSF1#517, SMARCA5#562 ISWI-containing factor RSF SMARCA5/SNF2H(ISWI-type ATPase), RSF1 RSF1_HUMAN, SMCA5_HUMAN 12972596, 25486562 chromatin remodeling complex 12972596 chromatin centromeric CENP-A chromatin # # 19398759 Assembly of regular nucleosome arrays.
ISWI CHRAC
(details)
Updated CHRAC1#132, POLE3#448, BAZ1A#62, SMARCA5#562 # CHRAC1, POLE3, ACF1 and ISWI/SNF2H CHRC1_HUMAN, DPOE3_HUMAN, BAZ1A_HUMAN, SMCA5_HUMAN 10880450, 10801849, 25486562 chromatin remodeling complex 10880450 chromatin # # # # #
ISWI NoRC
(details)
Updated BAZ2A#64, SMARCA5#562 # SMARCA5/SNF2H(ISWI-type ATPase), BAZ2A/TIP5 BAZ2A_HUMAN, SMCA5_HUMAN 11532953, 25486562 chromatin remodeling complex 11532953 chromatin # # # # A complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
ISWI NuRF
(details)
Updated BPTF#69, RBBP4#497, RBBP7#499, SMARCA1#559 nucleosome-remodeling factor SMARCA1; BPTF; RBBP4 and RBBP7 BPTF_HUMAN, RBBP4_HUMAN, RBBP7_HUMAN, SMCA1_HUMAN 20850016, 22108599 chromatin remodeling complex 20850016 chromatin # # # # Nucleosome-remodeling factor, a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Members: by similarity to mice.
ISWI CERF
(details)
New CECR2#117, SMARCA1#559 CECR2-containing-remodeling factor CECR2, SMCA1 CECR2_HUMAN, SMCA1_HUMAN 25486562 chromatin remodeling complex 25486562 chromatin # # # # #
SWI/SNF BAF
(details)
Updated ACTL6A#4, ACTL6B#5, ACTB#3, ARID1A#30, ARID1B#31, DPF3#174?, SMARCA2#560, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, SMARCB1#565, (SMARCD1#568|SMARCD2#569|SMARCD3#570)+ SWI/SNF-A (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. ACL6A_HUMAN, ACL6B_HUMAN, ACTB_HUMAN, ARI1A_HUMAN, ARI1B_HUMAN, DPF3_HUMAN?, SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SNF5_HUMAN, (SMRD1_HUMAN|SMRD2_HUMAN|SMRD3_HUMAN)+ 10078207, 11078522 chromatin remodeling complex 10078207 chromatin # # # # In muscle cells, the BAF complex also contains DPF3, which specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac).
SWI/SNF nBAF
(details)
Updated ACTL6B#5, ACTB#3, (ARID1A#30|ARID1B#31), DPF1#172, DPF3#174, SMARCA2#560, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, SMARCD1#568, SMARCD3#570, SMARCB1#565 neuron-specific chromatin remodeling complex ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin ACL6B_HUMAN, ACTB_HUMAN, (ARI1A_HUMAN|ARI1B_HUMAN), DPF1_HUMAN, DPF3_HUMAN, SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD3_HUMAN, SNF5_HUMAN 10078207, 11078522, 18765789, by similarity chromatin remodeling complex 11078522 chromatin # # # # The neuron-specific chromatin remodeling complex. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.
SWI/SNF npBAF
(details)
Updated ACTL6A#4, ACTB#3, (ARID1A#30|ARID1B#31), SMARCA2#560, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, SMARCD1#568, SMARCD3#570, SMARCB1#565, PHF10#433 neural progenitors-specific chromatin remodeling complex, BAF53 ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin ACL6A_HUMAN, ACTB_HUMAN, (ARI1A_HUMAN|ARI1B_HUMAN), SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD3_HUMAN, SNF5_HUMAN, PHF10_HUMAN 10078207, 11078522, 18765789, by similarity chromatin remodeling complex 11078522 chromatin # # # # Neural progenitors-specific chromatin remodeling complex. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.
SWI/SNF PBAF
(details)
Updated (ACTL6A#4|ACTL6B#5), ACTB#3, (ARID1A#30|ARID1B#31), ARID2#32, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, SMARCD1#568, SMARCD2#569, SMARCD3#570?, SMARCB1#565, PBRM1#420 SWI/SNF-B SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin (ACL6A_HUMAN|ACL6B_HUMAN), ACTB_HUMAN, (ARI1A_HUMAN|ARI1B_HUMAN), ARID2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD2_HUMAN, SMRD3_HUMAN?, SNF5_HUMAN, PB1_HUMAN 11078522, 11780067, 15985610 chromatin remodeling complex 11780067 chromatin # # # # Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.
SWI/SNF SWI/SNF_Brg1(I)
(details)
Updated (ACTL6A#4|ACTL6B#5), ARID1A#30, HDAC2#244?, SIN3A#552, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, (SMARCD1#568|SMARCD2#569|SMARCD3#570)+, SMARCB1#565, RBBP4#497? # SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, and probably HDAC2 and RBAP4 (ACL6A_HUMAN|ACL6B_HUMAN), ARI1A_HUMAN, HDAC2_HUMAN?, SIN3A_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, (SMRD1_HUMAN|SMRD2_HUMAN|SMRD3_HUMAN)+, SNF5_HUMAN, RBBP4_HUMAN? Uniprot chromatin remodeling complex Uniprot chromatin # # # # #
SWI/SNF SWI/SNF_Brg1(II)
(details)
Updated (ACTL6A#4|ACTL6B#5), ARID1A#30, HDAC2#244?, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, SMARCB1#565, RBBP4#497? # SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A and probably HDAC2 and RBAP4 (ACL6A_HUMAN|ACL6B_HUMAN), ARI1A_HUMAN, HDAC2_HUMAN?, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SNF5_HUMAN, RBBP4_HUMAN? Uniprot chromatin remodeling complex Uniprot chromatin # # # # #
SWI/SNF SWI/SNF_Brm
(details)
Updated (ACTL6A#4|ACTL6B#5), ARID1A#30, HDAC1#241, HDAC2#244, SIN3A#552, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, (SMARCD1#568|SMARCD2#569|SMARCD3#570)+, SMARCB1#565, RBBP4#497 # SMARCA2/BRM/BAF190B, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, HDAC1, HDAC2, and RBAP4. (ACL6A_HUMAN|ACL6B_HUMAN), ARI1A_HUMAN, HDAC1_HUMAN, HDAC2_HUMAN, SIN3A_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, (SMRD1_HUMAN|SMRD2_HUMAN|SMRD3_HUMAN)+, SNF5_HUMAN, RBBP4_HUMAN Uniprot chromatin remodeling complex Uniprot chromatin # # # # #
SWI/SNF SWI/SNF-like_EPAFa
(details)
Updated ACTL6A#4, ARID1B#31, MLLT1#359, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, SMARCD1#568, SMARCB1#565 # SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL ACL6A_HUMAN, ARI1B_HUMAN, ENL_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SNF5_HUMAN 12665591 chromatin remodeling complex 12665591 chromatin # # # # #
SWI/SNF WINAC
(details)
Updated ACTL6A#4, ARID1A#30, BAZ1B#63, CHAF1B#120, SMARCA2#560, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, SMARCD1#568, SMARCB1#565, SUPT16H#592, TOP2B#641 # ACL6A, ARI1A, BAZ1B/WSTF, CAF1A, SMCA2, SMCA4, SMCE1, SMRC1, SMRC2, SMRD1, SNF5, SP16H, TOP2B ACL6A_HUMAN, ARI1A_HUMAN, BAZ1B_HUMAN, CAF1B_HUMAN, SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SNF5_HUMAN, SP16H_HUMAN, TOP2B_HUMAN 12837248 chromatin remodeling complex 12837248 chromatin # # # # A chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. "directly interacts with the vitamin D receptor (VDR) through the Williams syndrome transcription factor (WSTF)".
SWI/SNF CERF
(details)
New CECR2#117, SMARCA1#559 CECR2-containing-remodeling factor complex CECR2, SMARCA1 CECR2_HUMAN, SMCA1_HUMAN 15640247 chromatin remodeling complex 15640247 chromatin # # # # facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis.
SWI/SNF SWI/SNF-like EPAFB
(details)
Updated ACTL6A#4, ACTB#3, ARID1B#31, MLLT1#359, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, SMARCD1#568, SMARCD2#569, SMARCB1#565 EPAFB SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, SMARCC1/BAF155, SMARCC2/BAF170, ARID1B/BAF250B, MLLT1/ENL and actin. ACL6A_HUMAN, ACTB_HUMAN, ARI1B_HUMAN, ENL_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD2_HUMAN, SNF5_HUMAN 12665591 chromatin remodeling complex 12665591 chromatin # # # # #
SWI/SNF bBAF
(details)
Updated ACTB#3, ARID1A#30, SMARCA2#560, SMARCA4#561, SMARCE1#571, SMARCC1#566, SMARCC2#567, SMARCD2#569, SMARCB1#565 # actin (ACTB), ARID1A/BAF250, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCC2/BAF170, SMARCD2/BAF60B and SMARCE1/BAF57 ACTB_HUMAN, ARI1A_HUMAN, SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD2_HUMAN, SNF5_HUMAN Uniprot (by similarity) chromatin remodeling complex Uniprot (by similarity) chromatin # # # # #
SWI/SNF SWI/SNF BRM-BRG1
(details)
Updated ACTL6A#4, ACTL6B#5, ARID1A#30, ARID1B#31, ACTB#3, BRD7#77, BRD9#79, DPF1#172, DPF3#174, SMARCA2#560, SMARCA4#561, SMARCC1#566, SMARCC2#567, SMARCD1#568, SMARCD2#569, SMARCD3#570, SMARCB1#565, PBRM1#420, PHF10#433, DPF2#173 # BRM, BRG1, actin, BAF45A, BAF45B, BAF45C, BAF45D, BAF47, BAF53A, BAF53B, BAF60A, BAF60B, BAF60C, BAF155, BAF170, BAF180, BAF200, BAF250A, BAF250B, BAP57, BRD7, BRD9 ACL6A_HUMAN, ACL6B_HUMAN, ARI1A_HUMAN, ARI1B_HUMAN, ACTB_HUMAN, BRD7_HUMAN, BRD9_HUMAN, DPF1_HUMAN, DPF3_HUMAN, SMCA2_HUMAN, SMCA4_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD2_HUMAN, SMRD3_HUMAN, SNF5_HUMAN, PB1_HUMAN, PHF10_HUMAN, REQU_HUMAN 22108599 chromatin remodeling complex 22108599 chromatin # # # # #
Ino80 Ino80
(details)
Updated ACTL6A#4, ACTR5#7, ACTR8#9, INO80#282, INO80B#283, INO80C#284, INO80D#285, MCRS1#351, NFRKB#396, RUVBL1#518, RUVBL2#519, TFPT#631, YY1#699, UCHL5#665 INO80C # ACL6A_HUMAN, ARP5_HUMAN, ARP8_HUMAN, INO80_HUMAN, IN80B_HUMAN, IN80C_HUMAN, IN80D_HUMAN, MCRS1_HUMAN, NFRKB_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, TFPT_HUMAN, TYY1_HUMAN, UCHL5_HUMAN 16230350 chromatin remodeling complex 16230350 chromatin, histone H2AS139ph # H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN 15607974 The chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
SWR SWR
(details)
New ANP32E#18, BRD8#78, EP400#194, ING3#279, KAT5#300, RUVBL1#518, RUVBL2#519, TRRAP#649 SWR1-like complex, SWR-C, SWR1-C # AN32E_HUMAN, BRD8_HUMAN, EP400_HUMAN, ING3_HUMAN, KAT5_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, TRRAP_HUMAN 24463511 chromatin remodeling complex 24463511 chromatin # # # # #
APOB mRNA editosome APOB_mRNA_editosome
(details)
# APOBEC1#21, APOBEC3F#27, APOBEC3G#28, APOBEC3H#29, A1CF#2, AICDA#12, SYNCRIP#601 Appoprotein B, APOBEC1, apolipoprotein B mRNA editing enzyme complex A1CF, APOBEC3F, APOBEC3G, APOBEC3H, APOBEC1, AICDA, SYNCRIP ABEC1_HUMAN, ABC3F_HUMAN, ABC3G_HUMAN, ABC3H_HUMAN, A1CF_HUMAN, AICDA_HUMAN, HNRPQ_HUMAN 17121840 mRNA editing complex 11727199 mRNA, DNA dC, mC dU, T # 11727199 Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
HAT PCAF
(details)
# SUPT3H#593, TADA2A#603, TADA3#605, TAF5L#614, TAF6L#616, TAF10#607, TAF12#608, TRRAP#649, TAF9#619 # TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP SUPT3_HUMAN, TAD2A_HUMAN, TADA3_HUMAN, TAF5L_HUMAN, TAF6L_HUMAN, TAF10_HUMAN, TAF12_HUMAN, TRRAP_HUMAN, TAF9_HUMAN, 9674425 histone acetylation complex 8684459 histone H3K14, H3K18, H4K5, H4K8 H3K14ac, H3K18ac, H4K5ac, H4K8ac H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN 9880483 #
HAT HBO1
(details)
# MEAF6#353, (ING4#280|ING5#281), (JADE1#287|JADE2#288|JADE3#289)+, KAT7#303 # ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 EAF6_HUMAN, (ING4_HUMAN|ING5_HUMAN), (JADE1_HUMAN|JADE2_HUMAN|JADE3_HUMAN)+, KAT7_HUMAN 16387653 histone acetylation complex 10438470 histone H3, H4 H3ac, H4ac H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN 10438470 Has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription.
HAT TFTC-HAT
(details)
# KAT2A#298, SUPT7L#595, TADA2B#604, TADA3#605, TAF2#610, TAF4#612, TAF5#613, TAF5L#614, TAF6#615, TAF6L#616, TAF9B#620, TAF10#607, TRRAP#649 hTFTC, TFTC KAT2A, SUPT3, TAD2B, TADA3, TADA3, TAF10, TAF2, TAF4, TAF5, TAF5L, TAF6, TAF6L, TAF9B, TRRAP KAT2A_HUMAN, ST65G_HUMAN, TAD2B_HUMAN, TADA3_HUMAN, TAF2_HUMAN, TAF4_HUMAN, TAF5_HUMAN, TAF5L_HUMAN, TAF6_HUMAN, TAF6L_HUMAN, TAF9B_HUMAN, TAF10_HUMAN, TRRAP_HUMAN 10373431 histone acetylation complex 10373431 histone H3 H3ac H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN 11406595 TATA binding protein free TAFII-containing transcription complex.
HAT Pol2 elongator
(details)
Updated IKBKAP#274, ELP2#187, ELP3#188, ELP4#189, ELP5#190, ELP6#191 RNA polymerase II elongator complex ELP1, ELP2, ELP3, ELP4, ELP5, ELP6 ELP1_HUMAN, ELP2_HUMAN, ELP3_HUMAN, ELP4_HUMAN, ELP5_HUMAN, ELP6_HUMAN 11714725, 11818576 histone acetylation complex 11714725 histone H3, H4 H3ac, H4ac H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN 11714725 A histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Original name "RNA polymerase II elongator complex".
HAT NuA4
(details)
# ACTL6A#4, ACTB#3, BRD8#78, DMAP1#162, MEAF6#353, EP400#194, EPC1#195, ING3#279, KAT5#300, MORF4L1#362, MORF4L2#363, MRGBP#366, RUVBL1#518, RUVBL2#519, TRRAP#649, VPS72#684, YEATS4#695 # KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 ACL6A_HUMAN, ACTB_HUMAN, BRD8_HUMAN, DMAP1_HUMAN, EAF6_HUMAN, EP400_HUMAN, EPC1_HUMAN, ING3_HUMAN, KAT5_HUMAN, MO4L1_HUMAN, MO4L2_HUMAN, MRGBP_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, TRRAP_HUMAN, VPS72_HUMAN, YETS4_HUMAN 14966270, 16387653 histone acetylation complex 14966270 histone H4, H2A H4ac, H2Aac H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN, H4_HUMAN 14966270 Is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.
HAT Piccolo_NuA4
(details)
# EPC1#195, ING3#279, KAT5#300 minimal HAT complex HTATTIP/TIP60, EPC1, and ING3 EPC1_HUMAN, ING3_HUMAN, KAT5_HUMAN 14966270 histone acetylation complex 14966270 histone H4, H2A H4ac, H2Aac H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN, H4_HUMAN 14966270 Target is defined by similarity to yeast.
HAT MOZ/MORF
(details)
Updated (BRPF1#84|BRPF3#85|BRD1#73), MEAF6#353, ING5#281, KAT6A#301, KAT6B#302 # ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (BRPF1_HUMAN|BRPF3_HUMAN|BRD1_HUMAN), EAF6_HUMAN, ING5_HUMAN, KAT6A_HUMAN, KAT6B_HUMAN 16387653, 18794358 histone acetylation complex 16387653 histone H3 H3ac H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN 16387653 Has a histone H3 acetyltransferase activity.
HAT SAGA
(details)
# ATXN7L3#53, ATXN7#52, ENY2#192, KAT2A#298, SUPT3H#593, TAF10#607, TRRAP#649, USP22#675 # ATXN7, ATXN7L3, ENY2, KAT2A, SUPT3H, TAF10, TRRAP and USP22 AT7L3_HUMAN, ATX7_HUMAN, ENY2_HUMAN, KAT2A_HUMAN, SUPT3_HUMAN, TAF10_HUMAN, TRRAP_HUMAN, UBP22_HUMAN 10637607, 17337012 histone acetylation complex, histone deubiquitination complex 18206972 histone H2A, H2B, H2Aub, H2Bub H2Aac, H2Bac, H2A, H2B H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN, H2B1A_HUMAN, H2B1B_HUMAN, H2B1C_HUMAN, H2B1D_HUMAN, H2B1H_HUMAN, H2B1J_HUMAN, H2B1K_HUMAN, H2B1L_HUMAN, H2B1M_HUMAN, H2B1N_HUMAN, H2B1O_HUMAN, H2B2C_HUMAN, H2B2D_HUMAN, H2B2E_HUMAN, H2B2F_HUMAN, H2B3B_HUMAN, H2BFM_HUMAN, H2BFS_HUMAN, H2BWT_HUMAN 18206972 Histone acetylation (HAT) complex, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.
HAT ATAC
(details)
# CSRP2BP#142, KAT2A#298, MBIP#349, DR1#177, CCDC101#101, TADA2A#603, TADA3#605, WDR5#687, YEATS2#694, ZZZ3#720 ADA2A-containing complex CSRP2BP, KAT2A, MBIP, DR1, CCDC101, TADA2A, TADA3, WDR5, YEATS2, ZZZ3 CSR2B_HUMAN, KAT2A_HUMAN, MBIP1_HUMAN, NC2B_HUMAN, SGF29_HUMAN, TAD2A_HUMAN, TADA3_HUMAN, WDR5_HUMAN, YETS2_HUMAN, ZZZ3_HUMAN 19103755 histone acetylation complex 19103755 histone H3, H4 H3ac, H4ac H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN 19103755 A complex with histone acetyltransferase activity on histones H3 and H4.
HAT NSL
(details)
# HCFC1#239, KANSL1#295, KANSL2#296, KANSL3#297, KAT8#304, MCRS1#351, PHF20#439, OGT#406, WDR5#687 # MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 HCFC1_HUMAN, KANL1_HUMAN, KANL2_HUMAN, KANL3_HUMAN, KAT8_HUMAN, MCRS1_HUMAN, PHF20_HUMAN, OGT1_HUMAN, WDR5_HUMAN 20018852 histone acetylation complex 20018852 histone H4K16 H4K16ac H4_HUMAN 20018852 It is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
HAT NuA4-related complex
(details)
# ACTL6A#4, ACTB#3, BRD8#78, DMAP1#162, EP400#194, EPC1#195, RUVBL1#518, RUVBL2#519, SRCAP#584, TRRAP#649, VPS72#684, YEATS4#695 NuA4-related SCRAP-containing complex EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41 ACL6A_HUMAN, ACTB_HUMAN, BRD8_HUMAN, DMAP1_HUMAN, EP400_HUMAN, EPC1_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, SRCAP_HUMAN, TRRAP_HUMAN, VPS72_HUMAN, YETS4_HUMAN Uniprot histone acetylation complex Uniprot histone # # # # #
HAT STAGA
(details)
# KAT2A#298, SUPT3H#593, SUPT7L#595, TADA1#602, TADA3#605, TAF5L#614, TAF6L#616, TAF9#619, TAF10#607, TAF12#608, TRRAP#649 # SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3, TAD1L, TAF10, TAF12, TRRAP and TAF9 KAT2A_HUMAN, SUPT3_HUMAN, ST65G_HUMAN, TADA1_HUMAN, TADA3_HUMAN, TAF5L_HUMAN, TAF6L_HUMAN, TAF9_HUMAN, TAF10_HUMAN, TAF12_HUMAN, TRRAP_HUMAN 11564863, 10637607, 17337012 histone acetylation complex 11564863 histone # # # # Complex with histone acetyltransferase activity, TAD1L is most likely a typo for TADA1L (=TADA1_HUMAN).
HDAC NuRD
(details)
Updated CHD3#124, CHD4#125, HDAC1#241, HDAC2#244, KDM1A#305, MBD2#344, MBD3#345, MTA1#372, MTA2#373, MTA3#374, (GATAD2A#229|GATAD2B#230), RBBP4#497, RBBP7#499 NRD, CHD3/CHD4 HDAC1, HDAC2, RBBP4, RBBP7, MTA1, MTA2, MTA3, MBD2, MBD3, p66, CHD3 or CHD4, LSD1 CHD3_HUMAN, CHD4_HUMAN, HDAC1_HUMAN, HDAC2_HUMAN, KDM1A_HUMAN, MBD2_HUMAN, MBD3_HUMAN, MTA1_HUMAN, MTA2_HUMAN, MTA3_HUMAN, (P66A_HUMAN|P66B_HUMAN), RBBP4_HUMAN, RBBP7_HUMAN 19644445, 10589671, 17289569, 22108599 histone deacetylation complex, histone methylation complex, chromatin remodelling complex 10589671, 22108599 histone H3 # H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN 11850414 The nucleosome remodeling and histone deacetylation complex.
HDAC BHC
(details)
Updated GSE1#234?, GTF2I#236?, HDAC1#241, HDAC2#244, HMG20B#262, KDM1A#305, PHF21A#441, RCOR1#502, ZMYM2#707?, ZMYM3#708?, ZNF217#711? BRAF-HDAC HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I GSE1_HUMAN?, GTF2I_HUMAN?, HDAC1_HUMAN, HDAC2_HUMAN, HM20B_HUMAN, KDM1A_HUMAN, PF21A_HUMAN, RCOR1_HUMAN, ZMYM2_HUMAN?, ZMYM3_HUMAN?, ZN217_HUMAN? 12493763 histone deacetylation complex 12493763 histone # # # # A corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells.
HDAC MeCP1
(details)
# HDAC1#241, HDAC2#244, MBD2#344 # MBD2, HDAC1 and HDAC2 HDAC1_HUMAN, HDAC2_HUMAN, MBD2_HUMAN 10471499 histone deacetylation complex, histone demethylation complex 10471499 histone # # # # #
HDAC mSin3A
(details)
# ARID4A#33, ARID4B#34, BRMS1#82, BRMS1L#83, HDAC1#241, HDAC2#244, SAP18#523, SAP30#525, SUDS3#591, SIN3A#552, SIN3B#553, RBBP4#497, RBBP7#499 Sin3, Sin3A SIN3A, SIN3B, RBBP4, RBBP7, SAP30, BRMS1, HDAC1 and HDAC2, BRMS1L, SUDS3, ARID4A, SAP18, SAP180 ARI4A_HUMAN, ARI4B_HUMAN, BRMS1_HUMAN, BRM1L_HUMAN, HDAC1_HUMAN, HDAC2_HUMAN, SAP18_HUMAN, SAP30_HUMAN, SDS3_HUMAN, SIN3A_HUMAN, SIN3B_HUMAN, RBBP4_HUMAN, RBBP7_HUMAN 12724404, 15451426 histone deacetylation complex 12670868 histone # # # # #
HDAC core HDAC
(details)
Updated HDAC1#241, HDAC2#244, RBBP4#497, RBBP7#499 # HDAC1, HDAC2, RBBP4 and RBBP7 HDAC1_HUMAN, HDAC2_HUMAN, RBBP4_HUMAN, RBBP7_HUMAN 12711221, 22108599 histone deacetylation complex 12711221 histone # # # # Original name "core histone deacetylase complex".
HDAC mSin3A-like complex
(details)
Updated HDAC1#241, HDAC2#244, ING2#278, SAP30#525, SIN3A#552, RBBP4#497, RBBP7#499 Sin3/HDAC1 corepressor complex SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2 HDAC1_HUMAN, HDAC2_HUMAN, ING2_HUMAN, SAP30_HUMAN, SIN3A_HUMAN, RBBP4_HUMAN, RBBP7_HUMAN 11784859, 16387653 histone deacetylation complex 16387653 histone # # # # #
PcG and PcG-like PRC1
(details)
Updated (CBX2#94|CBX4#96|CBX6#98|CBX7#99|CBX8#100), (BMI1#68|PCGF1#421|PCGF2#422|PCGF3#423|PCGF5#424|PCGF6#425), PHC2#430, (RING1#505|RNF2#509), (SCMH1#529|SCML2#530) PRC1.2, PRC1.4 # (CBX2_HUMAN|CBX4_HUMAN|CBX6_HUMAN|CBX7_HUMAN|CBX8_HUMAN), (BMI1_HUMAN|PCGF1_HUMAN|PCGF2_HUMAN|PCGF3_HUMAN|PCGF5_HUMAN|PCGF6_HUMAN), (PHC1_HUMAN, PHC2_HUMAN, PHC3_HUMAN), (RING1_HUMAN|RING2_HUMAN), (SCMH1_HUMAN| SCML2_HUMAN) 12167701, 22325352, 24217316 Polycomb group complex 23418308 histone H2AK119 H2AK119ub1 H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN 23418308 A complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. May modulate the levels of histone .H3K4Me3 by activating KDM5D histone demethylase.
PcG and PcG-like BCOR
(details)
Updated (BCOR#66|BCORL1#67), KDM2B#308, PCGF1#421, (RING1#505|RNF2#509), (RYBP#520|YAF2#693), SKP1#558, USP7#681 PRC1.1, RING2-KDM2B BCOR/BCORL1, RYBP/YAF2, PCGF1, RING1 or RNF2/RING2, KDM2B, USP7 and SKP1 (BCOR_HUMAN|BCORL_HUMAN), KDM2B_HUMAN, PCGF1_HUMAN, (RING1_HUMAN|RING2_HUMAN), (RYBP_HUMAN|YAF2_HUMAN), SKP1_HUMAN, UBP7_HUMAN 16943429, 22325352, 24217316 Polycomb like complex 16943429 histone H2AK119 H2AK119ub1 H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN # A complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A.
PcG and PcG-like RING2-L3MBTL2
(details)
New CBX3#95, E2F6#180, (HDAC1#241|HDAC2#244), L3MBTL2#331, MGA#356, PCGF6#425, (RING1#505|RNF2#509), (RYBP#520|YAF2#693), TFDP1#630, WDR5#687 PRC1.6 RING2, RYBP/YAF2, L3MBTL2, E2F6, PCGF6, CBX3, HDAC1/HDAC2, Dp-1, WDR5, MGA CBX3_HUMAN, E2F6_HUMAN, (HDAC1_HUMAN|HDAC2_HUMAN), LMBL2_HUMAN, MGAP_HUMAN, PCGF6_HUMAN, (RING1_HUMAN|RING2_HUMAN), (RYBP_HUMAN|YAF2_HUMAN), TFDP1_HUMAN, WDR5_HUMAN 22325352, 24217316 Polycomb like complex 22325352, 24217316 histone H2AK119 H2AK119ub1 H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN # #
PcG and PcG-like RING2-FBRS
(details)
New CSNK2A1#141, (FBRS#217|FBRSL1#218), (PCGF3#423|PCGF5#424), (RING1#505|RNF2#509), (RYBP#520|YAF2#693) PRC1.3, PRC1.5 RING1/RING2, FBRS/FBRSL1, RYBP/YAF2, PCGF3/PCGF5, CSNK2A1 CSK21_HUMAN, (FBRS_HUMAN|FBSL_HUMAN), (PCGF3_HUMAN|PCGF5_HUMAN), (RING1_HUMAN|RING2_HUMAN), (RYBP_HUMAN|YAF2_HUMAN) 22325352, 24217316 Polycomb like complex 22325352, 24217316 histone H2AK119 H2AK119ub1 H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN # #
PcG and PcG-like PRC2
(details)
Updated AEBP2#11, (JARID2#291|PHF1#432|MTF2#375|PHF19#437)?, EED#181, (EZH1#212|EZH2#213), SUZ12#600, (RBBP4#497|RBBP7#499) # EED, EZH1, SUZ12, RBBP4, RBBP7, JARID2 or PHF1 or PCL and AEBP2 AEBP2_HUMAN, (JARD2_HUMAN|PHF1_HUMAN|MTF2_HUMAN|PHF19_HUMAN)?, EED_HUMAN, (EZH1_HUMAN|EZH2_HUMAN), SUZ12_HUMAN, (RBBP4_HUMAN|RBBP7_HUMAN) 20075857, 23104054, 23273982, 22325352, 24217316 Polycomb group complex 15225548, 20075857 histone H3K9, H3K27 H3K9me1, H3K9me2, H3K9me3, H3K27me1, H3K27me2, H3K27me3 H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN 15225548, 20075857 Methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, EZH1 is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
HMT COMPASS
(details)
New ASH2L#40, CXXC1#154, DPY30#176, HCFC1#239, RBBP5#498, (SETD1A#535|SETD1B#536), WDR5#687, WDR82#689 SET1, Set1/Ash2 SETD1A, WDR5, WDR82P1, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 ASH2L_HUMAN, CXXC1_HUMAN, DPY30_HUMAN, HCFC1_HUMAN, RBBP5_HUMAN, (SET1A_HUMAN|SET1B_HUMAN), WDR5_HUMAN, WDR82_HUMAN 16253997 histone methylation complex 12670868 histone H3K4 H3K4me3 H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN 12670868 #
HMT Menin-associated_HMT
(details)
# ASH2L#40, DPY30#176, KMT2B#326, MEN1#355, RBBP5#498, WDR5#687 # KMT2B/MLL4, MEN1, ASH2L, RBBP5, DPY30 and WDR5 ASH2L_HUMAN, DPY30_HUMAN, KMT2B_HUMAN, MEN1_HUMAN, RBBP5_HUMAN, WDR5_HUMAN 17500065 histone methylation complex 17500065 histone H3K4 H3K4me H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN 16604156 #
HMT MLL-HCF
(details)
# ASH2L#40, DPY30#176, HCFC1#239, HCFC2#240, KMT2A#325, MEN1#355, RBBP5#498, WDR5#687 # KMT2A/MLL1, MEN1, ASH2L, RBBP5, DPY30, WDR5, HCFC1 and HCFC2 ASH2L_HUMAN, DPY30_HUMAN, HCFC1_HUMAN, HCFC2_HUMAN, KMT2A_HUMAN, MEN1_HUMAN, RBBP5_HUMAN, WDR5_HUMAN 15199122 histone methylation complex 15199122 histone # # # # #
HMT methylosome
(details)
Updated PRMT5#480, CLNS1A#137, WDR77#688 20S PRMT5-containing methyltransferase complex PRMT5, CLNS1A and WDR77 ANM5_HUMAN, ICLN_HUMAN, MEP50_HUMAN 11756452 histone methylation complex 11756452 histone H2AR H2ARme2 # # #
HMT eNoSc
(details)
Updated RRP8#516, SUV39H1#596, SIRT1#554 # SIRT1, SUV39H1 and RRP8 RRP8_HUMAN, SUV91_HUMAN, SIR1_HUMAN 18485871 histone methylation complex, histone deacetylation complex 18485871 histone, DNA H3K9, H3K9ac H3K9me # # #
MLL CHD8
(details)
Updated ASH2L#40, C17orf49#91?, CHD8#129, DPY30#176, E2F6#180?, HCFC1#239?, HCFC2#240?, (HSPA1A#271|HSPA1B#272)?, INO80C#284?, KANSL1#295?, KAT8#304?, KDM6A#320?, KMT2A#325, LAS1L#334?, MAX#341?, MCRS1#351?, MEN1#355?, MGA#356?, NCOA6#391?, PAGR1#412?, PAXIP1#418?, PELP1#428?, PHF20#439?, PRPF31#485?, RBBP5#498, RNF2#509?, RUVBL1#518?, RUVBL2#519?, SENP3#533?, TAF1#606?, TAF4#612?, TAF6#615?, TAF7#617?, TAF9#619?, TEX10#629?, WDR5#687 MLL1/MLL, CHD8 ASH2L, RBBP5, WDR5, DPY30, MLL and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, KMT2A_HUMAN, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, NCOA6_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?, RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN 15960975, 22108599 histone methylation complex, histone acetylation complex 19556245 histone H3K4, H4K16 H3K4me, H4K16ac H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN 19556245 A multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).
MLL MLL2/3
(details)
# ASH2L#40, C17orf49#91?, CHD8#129?, DPY30#176, E2F6#180?, HCFC1#239?, HCFC2#240?, (HSPA1A#271|HSPA1B#272)?, INO80C#284?, KANSL1#295?, KAT8#304?, KDM6A#320?, (KMT2B#326|KMT2C#327)+, LAS1L#334?, MAX#341?, MCRS1#351?, MEN1#355?, MGA#356?, NCOA6#391?, PAGR1#412?, PAXIP1#418?, PELP1#428?, PHF20#439?, PRPF31#485?, RBBP5#498, RNF2#509?, RUVBL1#518?, RUVBL2#519?, SENP3#533?, TAF1#606?, TAF4#612?, TAF6#615?, TAF7#617?, TAF9#619?, TEX10#629?, WDR5#687 ASCOM ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (MLL2/ALR and MLL3), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN?, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, (KMT2B_HUMAN|KMT2C_HUMAN)+, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, NCOA6_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?, RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN 17500065 histone methylation complex, histone acetylation complex 17500065 histone H3K4 H3K4me3 # 21330447 #
MLL COMPASS-like MLL1,2
(details)
New ASH2L#40, DPY30#176, HCFC1#239, KAT8#304, (KMT2A#325|KMT2D#328), MEN1#355, RBBP5#498, WDR5#687 # MLL1 or MLL2, MOF, Menin, ASH2L, DRY30, HCF1, RBBP5, WDR5 ASH2L_HUMAN, DPY30_HUMAN, HCFC1_HUMAN, KAT8_HUMAN, (KMT2A_HUMAN|KMT2D_HUMAN), MEN1_HUMAN, RBBP5_HUMAN, WDR5_HUMAN 22108599 histone methylation complex, histone acetylation complex 22108599 histone H4K16 H4K16ac H4_HUMAN 22108599 Hox-family gene regulator; tumor supressor activity.
MLL MLL4/WBP7
(details)
# ASH2L#40, C17orf49#91?, CHD8#129?, DPY30#176, E2F6#180?, HCFC1#239?, HCFC2#240?, (HSPA1A#271|HSPA1B#272)?, INO80C#284?, KANSL1#295?, KAT8#304?, KDM6A#320?, KMT2D#328, LAS1L#334?, MAX#341?, MCRS1#351?, MEN1#355?, MGA#356?, PAGR1#412?, PAXIP1#418?, PELP1#428?, PHF20#439?, PRPF31#485?, RBBP5#498, RNF2#509?, RUVBL1#518?, RUVBL2#519?, SENP3#533?, TAF1#606?, TAF4#612?, TAF6#615?, TAF7#617?, TAF9#619?, TEX10#629?, WDR5#687 # ASH2L, RBBP5, WDR5, DPY30, MLL4/WBP7, and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN?, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, KMT2D_HUMAN, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?,RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN, Uniprot histone methylation complex, histone acetylation complex Uniprot histone # # # # #
MLL COMPASS-like MLL3,4
(details)
New ASH2L#40, DPY30#176, KDM6A#320, (KMT2B#326|KMT2C#327|KMT2D#328), NCOA6#391, PAGR1#412, PAXIP1#418, RBBP5#498, WDR5#687 # MLL3 or MLL4, UTX, NCOA6, PA1, PTIP, ASH2L, DRY30, RBBP5, WDR5 ASH2L_HUMAN, DPY30_HUMAN, KDM6A_HUMAN, (KMT2B_HUMAN|KMT2C_HUMAN|KMT2D_HUMAN), NCOA6_HUMAN, PAGR1_HUMAN, PAXI1_HUMAN, RBBP5_HUMAN, WDR5_HUMAN 22108599 histone demethylation complex, histone acetylation complex 22108599 histone # # # # #
FACT FACT
(details)
# SSRP1#589, SUPT16H#592 # SSRP1 and SUPT16H SSRP1_HUMAN, SP16H_HUMAN 10421373 chromatin remodeling complex 16713563 chromatin, histone H2A, H2B # H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN, H2B1A_HUMAN, H2B1B_HUMAN, H2B1C_HUMAN, H2B1D_HUMAN, H2B1H_HUMAN, H2B1J_HUMAN, H2B1K_HUMAN, H2B1L_HUMAN, H2B1M_HUMAN, H2B1N_HUMAN, H2B1O_HUMAN, H2B2C_HUMAN, H2B2D_HUMAN, H2B2E_HUMAN, H2B2F_HUMAN, H2B3B_HUMAN, H2BFM_HUMAN, H2BFS_HUMAN, H2BWT_HUMAN 16713563 A general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
SRCAP SRCAP
(details)
# ACTL6A#4, ACTR6#8, DMAP1#162, SRCAP#584, RUVBL1#518, RUVBL2#519, YEATS4#695, ZNHIT1#718 # SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1 ACL6A_HUMAN, ARP6_HUMAN, DMAP1_HUMAN, SRCAP_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, YETS4_HUMAN, ZNHI1_HUMAN 15647280 chromatin remodeling complex 15647280 chromatin, histone histone dimers containing H2B and H2A.Z mononucleosomes reconstituted with recombinant H2A,H2B,H3,H4 H2AZ_HUMAN, H2B1A_HUMAN, H2B1B_HUMAN, H2B1C_HUMAN, H2B1D_HUMAN, H2B1H_HUMAN, H2B1J_HUMAN, H2B1K_HUMAN, H2B1L_HUMAN, H2B1M_HUMAN, H2B1N_HUMAN, H2B1O_HUMAN, H2B2C_HUMAN, H2B2D_HUMAN, H2B2E_HUMAN, H2B2F_HUMAN, H2B3B_HUMAN, H2BFM_HUMAN, H2BFS_HUMAN, H2BWT_HUMAN 16634648, 17617668 Mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. SRCAP-containing complex supports ATP-dependent exchange of histone dimers containing H2B and H2A.Z into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4.
DUB BRISC
(details)
# BABAM1#57, BRCC3#72, BRE#81, FAM175B#215 ABRO1 FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1 BABA1_HUMAN, BRCC3_HUMAN, BRE_HUMAN, F175B_HUMAN 19214193 histone deubiquitination complex 19214193 histone H2Aub, H2AXub H2A, H2AX H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN 14636569 #
DUB PR-DUB
(details)
# ASXL1#41, BAP1#60 # BAP1 and ASXL1 ASXL1_HUMAN, BAP1_HUMAN 20436459 histone deubiquitination complex 20436459 histone H2AK119 H2AK119ub1 H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN 20436459 A complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1).
DUB BRCC
(details)
# BRCA1#70, BRCA2#71, BARD1#61, BRE#81, RAD51#488 BRCA1/BRCA2 containing complex BRCA1, BRCA2, BARD1, BRE and RAD51 BRCA1_HUMAN, BRCA2_HUMAN, BARD1_HUMAN, BRE_HUMAN, RAD51_HUMAN 14636569 histone deubiquitination complex 14636569 histone # # # # #
DUB BRCA1-A
(details)
# BABAM1#57, BARD1#61, BRCA1#70, BRCC3#72, BRE#81, FAM175A#214, UIMC1#668 # BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1 BABA1_HUMAN, BARD1_HUMAN, BRCA1_HUMAN, BRCC3_HUMAN, BRE_HUMAN, F175A_HUMAN, UIMC1_HUMAN 19261746, 19261748, 19261749 histone deubiquitination complex 19261746, 19261748, 19261749 histone H2AK63ub, H2AXK63ub H2AK63, H2AXK63 H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN 19261746, 19261748, 19261749 A complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
CAF-1 CAF-1
(details)
# CHAF1A#119, CHAF1B#120, RBBP4#497 # RBBP4, CHAF1B and CHAF1A CAF1A_HUMAN, CAF1B_HUMAN, RBBP4_HUMAN 8858152 chromatin assembly complex 8858152 histone H3, H4 # H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN 8858152 Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
CREST-BRG1 CREST-BRG1
(details)
Updated SS18L1#587, HDAC1#241, SMARCA4#561, SP1#579, RB1#496 # SMARCA4/BRG1/BAF190A, SS18L1/CREST, HDAC1, RB1 and SP1 CREST_HUMAN, HDAC1_HUMAN, SMCA4_HUMAN, SP1_HUMAN, RB_HUMAN Uniprot (by similarity) chromatin remodeling complex Uniprot (by similarity) chromatin # # # # A multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex.
Exosome RNA exosome
(details)
# EXOSC1#199, EXOSC2#200, EXOSC3#201, EXOSC4#202, EXOSC5#203, EXOSC6#204, EXOSC7#205, EXOSC8#206, EXOSC9#207 RNA exosome complex EXOSC4, EXOSC9, EXOSC5, EXOSC8, EXOSC6, EXOSC7, EXOSC1, EXOSC2 and EXOSC3 EXOS1_HUMAN, EXOS2_HUMAN, EXOS3_HUMAN, EXOS4_HUMAN, EXOS5_HUMAN, EXOS6_HUMAN, EXOS7_HUMAN, EXOS8_HUMAN, EXOS9_HUMAN 17174896 RNA exosome complex 17174896 RNA # # # # #
PP PPP4C-PPP4R2-PPP4R3A
(details)
Updated PPP4C#452, PPP4R2#453, SMEK1#572 PP4 PPP4C, PPP4R2 and PPP4R3A PP4C_HUMAN, PP4R2_HUMAN, P4R3A_HUMAN 18758438 dephosporylation complex 18758438 histone H2AFXS139ph H2AFXS139 # 18758438 #
L3MBTL1 L3MBTL1
(details)
New CBX3#95, L3MBTL1#330, RB1#496 # L3MBTL1, HP1gamma, pRB CBX3_HUMAN, LMBL1_HUMAN, RB_HUMAN 17540172 chromatin remodeling complex 25482055 chromatin, histone H4K20me1, H4K20me2, H1bK26me1, H1bK26me2 # H14_HUMAN, H15_HUMAN, H4_HUMAN 17540172 #
CoREST SCL
(details)
New KDM1A#305, RCOR1#502, SFMBT1#548 # SFMBT1, LSD1, CoREST KDM1A_HUMAN, RCOR1_HUMAN, SMBT1_HUMAN 23592795 chromatin remodeling complex 25482055 histone H4K20 # H4_HUMAN 23592795 #
CoREST LSD-CoREST
(details)
New CTBP1#143, GSE1#234, HDAC1#241, HDAC2#244, HMG20A#261, HMG20B#262, PHF21A#441, RCOR1#502, RCOR3#503, ZMYM2#707, ZNF217#711, ZNF516#712 # CoREST, HDAC1, HDAC2, BHC80, BRAF35, CtBP, Znf217, Znf516, Znf198, KIAA0182, KIAA1343, HMG20A CTBP1_HUMAN, GSE1_HUMAN, HDAC1_HUMAN, HDAC2_HUMAN, HM20A_HUMAN, HM20B_HUMAN, PF21A_HUMAN, RCOR1_HUMAN, RCOR3_HUMAN, ZMYM2_HUMAN, ZN217_HUMAN, ZN516_HUMAN 16140033, 16079794 histone demethylation complex, histone acetylation complex 25482055 histone H3K4me3 # H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN # #