Gene info
| HGNC approved symbol | ZBTB33 |
| HGNC ID | HGNC:16682 |
| HGNC approved name | zinc finger and BTB domain containing 33 |
| Entrez gene ID | GeneID:10009 (SSTAR profile) |
| UniProt AC (human) | Q86T24 |
| UniProt ID (human) | KAISO_HUMAN |
| Pfam domains | BTB PF00651 (22-116) |
| MGI symbol | Zbtb33 |
| MGI ID | MGI:1927290 |
| UniProt AC (mouse) | Q8BN78 |
| UniProt ID (mouse) | KAISO_MOUSE |
| HGNC gene family tag | ZBTB, BTBD, ZNF |
| HGNC gene family description | BTB/POZ domain containing, Zinc fingers, C2H2-type |
| Function | Histone modification write cofactor, Histone modification erase cofactor, TF |
| Modification | Histone acetylation, Histone methylation, TF repressor |
| PMID for information on function | PMID:14527417 |
| Protein complex | # |
| Target molecule | DNA |
| Target entity | CG, mCG, DNA motif |
| HOCOMOCO TFBS model | |
| Product | # |
| PMID for information on target | PMID:14527417 |
| Comment | Kaiso, a methyl CpG binding protein belonging to the BTB/POZ family of transcription factors, is a component of the human N-CoR complex. In vitro, the Kaiso/N-CoR complex binds specific CpG-rich sequences in a methylation-dependent manner. In vivo, Kaiso targets the N-CoR complex to the MTA2 gene promoter in a methylation-dependent manner. This repression also requires a functional N-CoR deacetylase complex, which brings about histone hypoacetylation and methylation of H3 lysine 9 to the MTA2 locus. |
| Status of entry | # |
Expression statistics
| Expression range: | 0.0 to 107.72 |
| Mean expression: | 15.1 ± 9.94 |
| Median expression: | 12.84 |