| HGNC approved symbol | HDAC6 |
| HGNC ID | HGNC:14064 |
| HGNC approved name | histone deacetylase 6 |
| Entrez gene ID | GeneID:10013 (SSTAR profile) |
| UniProt AC (human) | Q9UBN7 |
| UniProt ID (human) | HDAC6_HUMAN |
| Pfam domains | Hist_deacetyl PF00850 (106-402, 499-798) zf-UBP PF02148 (1132-1193) |
| MGI symbol | Hdac6 |
| MGI ID | MGI:1333752 |
| UniProt AC (mouse) | Q9Z2V5 |
| UniProt ID (mouse) | HDAC6_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification erase |
| Modification | Histone acetylation |
| PMID for information on function | PMID:10220385 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2AKac, H2BKac, H3Kac, H4Kac |
| Product | H2AK, H2BK, H3K, H4K |
| PMID for information on target | PMID:10220385 |
| Comment | HDAC1, HDAC4, HDAC5, and HDAC6 deacetylate all four core histones equally well, though deacetylation by HDAC4 and HDAC5 is incomplete. (HDAC6 is possibly not involved in epigenetic signalling, but it deacetylates microtubules and heat shock protein 90; PMID:22498752) |
| Status of entry | # |
| Expression range: | 0.0 to 67.5 |
| Mean expression: | 13.32 ± 8.39 |
| Median expression: | 11.0 |