| HGNC approved symbol | SUPT16H |
| HGNC ID | HGNC:11465 |
| HGNC approved name | suppressor of Ty 16 homolog (S. cerevisiae) |
| Entrez gene ID | GeneID:11198 (SSTAR profile) |
| UniProt AC (human) | Q9Y5B9 |
| UniProt ID (human) | SP16H_HUMAN |
| Pfam domains | FACT-Spt16_Nlob PF14826 (5-167) Peptidase_M24 PF00557 (182-411) SPT16 PF08644 (529-689) Rttp106-like_middle PF08512 (809-895) SPT16_C PF21091 (929-1031) |
| MGI symbol | Supt16 |
| MGI ID | MGI:1890948 |
| UniProt AC (mouse) | Q920B9 |
| UniProt ID (mouse) | SP16H_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification read |
| Modification | # |
| PMID for information on function | PMID:12934006 |
| Protein complex | WINAC, FACT |
| Target molecule | histone |
| Target entity | H2A, H2B |
| Product | # |
| PMID for information on target | PMID:12934006 |
| Comment | Both FACT and Spt16=SUPT16H can bind to nucleosomes and H2A-H2B dimers, whereas SSRP1 can only bind to H3-H4 tetramers but not to intact nucleosomes. Possibly, upon FACT binding to the nucleosome in the transcribed region, Spt16 facilitates the H2A-H2B displacement, which promotes the interaction between SSRP1 and the “altered” nucleosome. |
| Status of entry | # |
| Expression range: | 2.01 to 137.96 |
| Mean expression: | 33.58 ± 21.21 |
| Median expression: | 27.96 |