HGNC approved symbol | DDB1 |
HGNC ID | HGNC:2717 |
HGNC approved name | damage-specific DNA binding protein 1, 127kDa |
Entrez gene ID | GeneID:1642 (SSTAR profile) |
UniProt AC (human) | Q16531 |
UniProt ID (human) | DDB1_HUMAN |
Pfam domains | MMS1_N PF10433 (75-542) CPSF_A PF03178 (788-1100) |
MGI symbol | Ddb1 |
MGI ID | MGI:1202384 |
UniProt AC (mouse) | Q3U1J4 |
UniProt ID (mouse) | DDB1_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write |
Modification | Histone ubiquitination |
PMID for information on function | PMID:16678110 |
Protein complex | # |
Target molecule | histone |
Target entity | H2A |
Product | # |
PMID for information on target | PMID:16678110 |
Comment | DDB1-CUL4ADDB2 E3 in vivo targets histone H2A for ubiquitination at UV-damage DNA sites, where DDB2 serves as the substrate receptor. |
Status of entry | # |
Expression range: | 2.99 to 454.68 |
Mean expression: | 111.08 ± 51.43 |
Median expression: | 106.41 |