| HGNC approved symbol | DNMT1 |
| HGNC ID | HGNC:2976 |
| HGNC approved name | DNA (cytosine-5-)-methyltransferase 1 |
| Entrez gene ID | GeneID:1786 (SSTAR profile) |
| UniProt AC (human) | P26358 |
| UniProt ID (human) | DNMT1_HUMAN |
| Pfam domains | DMAP_binding PF06464 (19-101) DNMT1-RFD PF12047 (394-535) zf-CXXC PF02008 (646-691) BAH PF01426 (755-878, 931-1100) DNA_methylase PF00145 (1140-1592) |
| MGI symbol | Dnmt1 |
| MGI ID | MGI:94912 |
| UniProt AC (mouse) | P13864 |
| UniProt ID (mouse) | DNMT1_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | DNA modification |
| Modification | DNA methylation |
| PMID for information on function | PMID:18754681 |
| Protein complex | # |
| Target molecule | DNA |
| Target entity | dhC |
| Product | dhU |
| PMID for information on target | PMID:18754681 |
| Comment | The CXXC region (C is cysteine; X is any amino acid) of DNMT1 binds specifically to unmethylated CpG dinucleotides. Thus, the CXXC domain encompassing the amino terminus region of DNMT1 cooperates with the catalytic domain for DNA methyltransferase activity. |
| Status of entry | # |
| Expression range: | 0.0 to 478.81 |
| Mean expression: | 41.22 ± 33.47 |
| Median expression: | 32.18 |