| HGNC approved symbol | EYA4 |
| HGNC ID | HGNC:3522 |
| HGNC approved name | EYA transcriptional coactivator and phosphatase 4 |
| Entrez gene ID | GeneID:2070
(SSTAR profile) |
| UniProt AC (human) | O95677 |
| UniProt ID (human) | EYA4_HUMAN |
| Pfam domains | Hydrolase PF00702 (370-614) |
| MGI symbol | Eya4 |
| MGI ID | MGI:1337104 |
| UniProt AC (mouse) | Q9Z191 |
| UniProt ID (mouse) | EYA4_MOUSE |
| HGNC gene family tag | PTPE |
| HGNC gene family description | Protein tyrosine phosphatases / Asp-based PTPs |
| Function | Histone modification erase |
| Modification | Histone phosphorylation |
| PMID for information on function | # |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2AXY142ph |
| Product | H2AXY142 |
| PMID for information on target | PMID:24096489 |
| Comment | In response to double-stranded breaks, EYA4 dephosphorylates the Tyr-142 residue of H2AX facilitating phosphorylation of Ser-139 of H2AX (forming γH2AX), leading to the recruitment of DNA repair complex components to sites of double-stranded break. |
| Status of entry | # |