| HGNC approved symbol | KDM2A |
| HGNC ID | HGNC:13606 |
| HGNC approved name | lysine (K)-specific demethylase 2A |
| Entrez gene ID | GeneID:22992 (SSTAR profile) |
| UniProt AC (human) | Q9Y2K7 |
| UniProt ID (human) | KDM2A_HUMAN |
| Pfam domains | JHD PF17811 (304-343) zf-CXXC PF02008 (565-609) PHD_4 PF16866 (615-676) F-box-like PF12937 (896-935) |
| MGI symbol | Kdm2a |
| MGI ID | MGI:1354736 |
| UniProt AC (mouse) | P59997 |
| UniProt ID (mouse) | KDM2A_MOUSE |
| HGNC gene family tag | FBXL, KDM |
| HGNC gene family description | F-boxes / Leucine-rich repeats, Chromatin-modifying enzymes / K-demethylases |
| Function | Histone modification erase |
| Modification | Histone methylation |
| PMID for information on function | PMID:20417597 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K36me2 |
| Product | H3K36 |
| PMID for information on target | PMID:20417597 |
| Comment | CpG islands directly recruit the H3K36-specific lysine demethylase enzyme KDM2A. Nucleation of KDM2A at these elements results in removal of H3K36 methylation, creating CpG island chromatin that is uniquely depleted of this modification. |
| Status of entry | # |
| Expression range: | 11.16 to 335.63 |
| Mean expression: | 45.08 ± 35.56 |
| Median expression: | 35.65 |