| HGNC approved symbol | SPEN |
| HGNC ID | HGNC:17575 |
| HGNC approved name | spen family transcriptional repressor |
| Entrez gene ID | GeneID:23013 (SSTAR profile) |
| UniProt AC (human) | Q96T58 |
| UniProt ID (human) | MINT_HUMAN |
| Pfam domains | RRM_1 PF00076 (8-67, 337-407, 439-508, 519-583) MINT_MID PF20809 (2012-3467) MINT_RID PF20810 (2366-2584, 3009-3469) MINT_RAM7 PF20808 (2654-2749) SPOC PF07744 (3506-3662) |
| MGI symbol | Spen |
| MGI ID | MGI:1891706 |
| UniProt AC (mouse) | Q62504 |
| UniProt ID (mouse) | MINT_MOUSE |
| HGNC gene family tag | RBM |
| HGNC gene family description | RNA binding motif (RRM) containing |
| Function | Histone modification erase cofactor, TF |
| Modification | Histone acetylation, TF activator, TF repressor |
| PMID for information on function | PMID:11331609 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | # |
| HOCOMOCO TFBS model | |
| Product | # |
| PMID for information on target | PMID:11331609 |
| Comment | SHARP =SPEN recruits histone deacetylase activity. SHARP is a potent transcriptional repressor whose repression domain (RD) interacts directly with SMRT and at least five members of the NuRD complex including HDAC1 and HDAC2. |
| Status of entry | # |
| Expression range: | 3.49 to 192.9 |
| Mean expression: | 28.2 ± 18.36 |
| Median expression: | 23.9 |