HGNC approved symbol | KDM6B |
HGNC ID | HGNC:29012 |
HGNC approved name | lysine (K)-specific demethylase 6B |
Entrez gene ID | GeneID:23135 (SSTAR profile) |
UniProt AC (human) | O15054 |
UniProt ID (human) | KDM6B_HUMAN |
Pfam domains | JmjC PF02373 (1377-1485) KDM6_C-hel PF21322 (1492-1547) KDM6_GATAL PF21326 (1560-1623) |
MGI symbol | Kdm6b |
MGI ID | MGI:2448492 |
UniProt AC (mouse) | Q5NCY0 |
UniProt ID (mouse) | KDM6B_MOUSE |
HGNC gene family tag | KDM |
HGNC gene family description | Chromatin-modifying enzymes / K-demethylases |
Function | Histone modification erase |
Modification | Histone methylation |
PMID for information on function | PMID:17851529 |
Protein complex | # |
Target molecule | histone |
Target entity | H3K27me2. H3K27me4 |
Product | H3K28 |
PMID for information on target | PMID:17851529 |
Comment | The JmjC-domain-containing proteins UTX=KDM6A and JMJD3=KDM6B catalyse demethylation of H3K27me3/2. |
Status of entry | # |
Expression range: | 0.0 to 898.13 |
Mean expression: | 5.02 ± 34.01 |
Median expression: | 1.03 |