| HGNC approved symbol | USP21 |
| HGNC ID | HGNC:12620 |
| HGNC approved name | ubiquitin specific peptidase 21 |
| Entrez gene ID | GeneID:27005
(SSTAR profile) |
| UniProt AC (human) | Q9UK80 |
| UniProt ID (human) | UBP21_HUMAN |
| Pfam domains | UCH PF00443 (212-555) |
| MGI symbol | Usp21 |
| MGI ID | MGI:1353665 |
| UniProt AC (mouse) | Q9QZL6 |
| UniProt ID (mouse) | UBP21_MOUSE |
| HGNC gene family tag | USP |
| HGNC gene family description | Ubiquitin-specific peptidases |
| Function | Histone modification erase |
| Modification | Histone ubiquitination |
| PMID for information on function | # |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2Aub |
| Product | H2A |
| PMID for information on target | # |
| Comment | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. (Annotated by similarity.) |
| Status of entry | # |