| HGNC approved symbol | MSH6 |
| HGNC ID | HGNC:7329 |
| HGNC approved name | mutS homolog 6 |
| Entrez gene ID | GeneID:2956 (SSTAR profile) |
| UniProt AC (human) | P52701 |
| UniProt ID (human) | MSH6_HUMAN |
| Pfam domains | PWWP PF00855 (92-182) MutS_I PF01624 (408-524) MutS_II PF05188 (538-693) MutS_III PF05192 (738-1064) MutS_IV PF05190 (932-1024) MutS_V PF00488 (1130-1324) |
| MGI symbol | Msh6 |
| MGI ID | MGI:1343961 |
| UniProt AC (mouse) | P54276 |
| UniProt ID (mouse) | MSH6_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification read |
| Modification | # |
| PMID for information on function | PMID:21423274 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K36me3 |
| Product | # |
| PMID for information on target | PMID:21423274, PMID:23622243 |
| Comment | Table 1 in the reference. Via its PWWP domain it specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. |
| Status of entry | # |
| Expression range: | 4.21 to 228.96 |
| Mean expression: | 38.16 ± 26.9 |
| Median expression: | 30.35 |