Gene info
| HGNC approved symbol | AIRE |
| HGNC ID | HGNC:360 |
| HGNC approved name | autoimmune regulator |
| Entrez gene ID | GeneID:326 (SSTAR profile) |
| UniProt AC (human) | O43918 |
| UniProt ID (human) | AIRE_HUMAN |
| Pfam domains | HSR PF03172 (5-102) SAND PF01342 (200-239) PHD PF00628 (299-340) |
| MGI symbol | Aire |
| MGI ID | MGI:1338803 |
| UniProt AC (mouse) | Q9Z0E3 |
| UniProt ID (mouse) | AIRE_MOUSE |
| HGNC gene family tag | PHF |
| HGNC gene family description | Zinc fingers, PHD-type |
| Function | Histone modification read, TF |
| Modification | # |
| PMID for information on function | PMID:18292755 |
| Protein complex | # |
| Target molecule | histone, DNA |
| Target entity | H3K4, H3K4me3, DNA motif |
| HOCOMOCO TFBS model | |
| Product | # |
| PMID for information on target | PMID:18292755 |
| Comment | AIRE selectively interacts with histone H3 through its first plant homeodomain (PHD) finger (AIRE–PHD1) and preferentially binds to non-methylated H3K4 (H3K4me0). Accordingly, in vivo AIRE binds to and activates promoters containing low levels of H3K4me3 in human embryonic kidney 293 cells. AIRE–PHD1 is an important member of a newly identified class of PHD fingers that specifically recognize H3K4me0, thus providing a new link between the status of histone modifications. |
| Status of entry | # |
Expression statistics
| Expression range: | 0.0 to 194.63 |
| Mean expression: | 0.34 ± 6.63 |
| Median expression: | 0.0 |