HGNC approved symbol | JAK2 |
HGNC ID | HGNC:6192 |
HGNC approved name | Janus kinase 2 |
Entrez gene ID | GeneID:3717 (SSTAR profile) |
UniProt AC (human) | O60674 |
UniProt ID (human) | JAK2_HUMAN |
Pfam domains | FERM_F1 PF18379 (39-133) FERM_F2 PF18377 (144-261) Jak1_Phl PF17887 (306-381) domain PF21990 (398-502) PK_Tyr_Ser-Thr PF07714 (545-805, 849-1122) |
MGI symbol | Jak2 |
MGI ID | MGI:96629 |
UniProt AC (mouse) | Q62120 |
UniProt ID (mouse) | JAK2_MOUSE |
HGNC gene family tag | SH2D |
HGNC gene family description | SH2 domain containing |
Function | Histone modification write |
Modification | Histone phosphorylation |
PMID for information on function | PMID:19783980 |
Protein complex | # |
Target molecule | histone |
Target entity | H3T41 |
Product | H3T41ph |
PMID for information on target | PMID:19783980 |
Comment | Human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3. |
Status of entry | # |
Expression range: | 0.0 to 187.97 |
Mean expression: | 13.08 ± 18.52 |
Median expression: | 7.1 |