| HGNC approved symbol | DND1 |
| HGNC ID | HGNC:23799 |
| HGNC approved name | DND microRNA-mediated repression inhibitor 1 |
| Entrez gene ID | GeneID:373863 (SSTAR profile) |
| UniProt AC (human) | Q8IYX4 |
| UniProt ID (human) | DND1_HUMAN |
| Pfam domains | RRM_1 PF00076 (60-122) DND1_DSRM PF14709 (256-331) |
| MGI symbol | Dnd1 |
| MGI ID | MGI:2447763 |
| UniProt AC (mouse) | Q6VY05 |
| UniProt ID (mouse) | DND1_MOUSE |
| HGNC gene family tag | RBM |
| HGNC gene family description | RNA binding motif (RRM) containing |
| Function | RNA modification |
| Modification | # |
| PMID for information on function | PMID:23890083 |
| Protein complex | # |
| Target molecule | RNA |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:23890083 |
| Comment | The RNA binding protein DEAD-END (DND1) is one of the few proteins known to regulate microRNA (miRNA) activity at the level of miRNA-mRNA interaction. APOBEC3G may bind mRNAs (maybe together with DND1) and subsequently interact with components of the miRISC to activate translation repression or interact with translation initiation factors to inhibit them. APOBEC3G may bind to DND1 and sequester it away from mRNAs and miRNAs, the cytidine deaminase activity of APOBEC3 may allow it to edit the 3′-UTR sequences of P27, LATS2 and CX43 to inhibit DND1 binding. |
| Status of entry | # |
| Expression range: | 0.0 to 6.07 |
| Mean expression: | 0.03 ± 0.32 |
| Median expression: | 0.0 |