HGNC approved symbol | ATM |
HGNC ID | HGNC:795 |
HGNC approved name | ATM serine/threonine kinase |
Entrez gene ID | GeneID:472 (SSTAR profile) |
UniProt AC (human) | Q13315 |
UniProt ID (human) | ATM_HUMAN |
Pfam domains | TAN PF11640 (2-128) FAT PF02259 (2089-2487) PI3_PI4_kinase PF00454 (2713-2963) FATC PF02260 (3026-3056) |
MGI symbol | Atm |
MGI ID | MGI:107202 |
UniProt AC (mouse) | Q62388 |
UniProt ID (mouse) | ATM_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write |
Modification | Histone phosphorylation |
PMID for information on function | PMID:19261749 |
Protein complex | # |
Target molecule | histone |
Target entity | H2AXS139 |
Product | # |
PMID for information on target | PMID:19261749 |
Comment | Damage-induced ATM/ATR phosphorylation on S139 of histone H2AX directly recruits MDC1 through MDC1’s BRCT domains. MDC1 itself is a substrate of ATM/ATR. |
Status of entry | # |
Expression range: | 0.0 to 153.3 |
Mean expression: | 22.33 ± 21.39 |
Median expression: | 16.07 |