| HGNC approved symbol | UBR5 |
| HGNC ID | HGNC:16806 |
| HGNC approved name | ubiquitin protein ligase E3 component n-recognin 5 |
| Entrez gene ID | GeneID:51366 (SSTAR profile) |
| UniProt AC (human) | O95071 |
| UniProt ID (human) | UBR5_HUMAN |
| Pfam domains | E3_UbLigase_EDD PF11547 (183-228) PABP PF00658 (2391-2450) HECT PF00632 (2505-2799) |
| MGI symbol | Ubr5 |
| MGI ID | MGI:1918040 |
| UniProt AC (mouse) | Q80TP3 |
| UniProt ID (mouse) | UBR5_MOUSE |
| HGNC gene family tag | UBR |
| HGNC gene family description | Ubiquitin protein ligase E3 component n-recognins |
| Function | Chromatin remodeling, Histone modification write cofactor |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:22884692 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2A, H2AX |
| Product | H2Aub, H2AXub |
| PMID for information on target | PMID:22884692 |
| Comment | Excessive spreading of a DNA-damage-associated chromatin modification can occur. TRIP12 and UBR5 are two suppressors of such spreading. |
| Status of entry | # |
| Expression range: | 4.21 to 170.62 |
| Mean expression: | 34.45 ± 19.18 |
| Median expression: | 30.65 |