| HGNC approved symbol | SIRT6 |
| HGNC ID | HGNC:14934 |
| HGNC approved name | sirtuin 6 |
| Entrez gene ID | GeneID:51548
(SSTAR profile) |
| UniProt AC (human) | Q8N6T7 |
| UniProt ID (human) | SIR6_HUMAN |
| Pfam domains | SIR2 PF02146 (85-221) |
| MGI symbol | Sirt6 |
| MGI ID | MGI:1354161 |
| UniProt AC (mouse) | P59941 |
| UniProt ID (mouse) | SIR6_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification erase |
| Modification | Histone acetylation |
| PMID for information on function | PMID:18337721 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K9ac, H3K56ac |
| Product | H3K9, H3K56 |
| PMID for information on target | PMID:18337721 |
| Comment | The human SIRT6 protein is an NAD+-dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres, and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. |
| Status of entry | # |