| HGNC approved symbol | MSL2 |
| HGNC ID | HGNC:25544 |
| HGNC approved name | male-specific lethal 2 homolog (Drosophila) |
| Entrez gene ID | GeneID:55167 (SSTAR profile) |
| UniProt AC (human) | Q9HCI7 |
| UniProt ID (human) | MSL2_HUMAN |
| Pfam domains | zf-RING_10 PF16685 (39-110) MSL2-CXC PF16682 (455-506) |
| MGI symbol | Msl2 |
| MGI ID | MGI:1925103 |
| UniProt AC (mouse) | Q69ZF8 |
| UniProt ID (mouse) | MSL2_MOUSE |
| HGNC gene family tag | RNF |
| HGNC gene family description | RING-type (C3HC4) zinc fingers |
| Function | Histone modification write |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:21726816 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2BK34 |
| Product | H2BK34ub |
| PMID for information on target | PMID:21726816 |
| Comment | RING finger protein MSL2 in the MOF-MSL complex is a histone ubiquitin E3 ligase. MSL2, together with MSL1, has robust histone ubiquitylation activity that mainly targets nucleosomal H2B on lysine 34 (H2B K34ub), a site within a conserved basic patch on H2B tail. |
| Status of entry | # |
| Expression range: | 0.0 to 152.82 |
| Mean expression: | 17.91 ± 19.77 |
| Median expression: | 11.46 |