| HGNC approved symbol | PRDM8 |
| HGNC ID | HGNC:13993 |
| HGNC approved name | PR domain containing 8 |
| Entrez gene ID | GeneID:56978 (SSTAR profile) |
| UniProt AC (human) | Q9NQV8 |
| UniProt ID (human) | PRDM8_HUMAN |
| Pfam domains | PRDM2_PR PF21549 (26-138) zf-C2H2_4 PF13894 (667-688) |
| MGI symbol | Prdm8 |
| MGI ID | MGI:1924880 |
| UniProt AC (mouse) | Q8BZ97 |
| UniProt ID (mouse) | PRDM8_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write |
| Modification | Histone methylation |
| PMID for information on function | PMID:23856557 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:23856557 |
| Comment | Some Prdms show intrinsic HKMTase activity (Prdm2, Prdm3, Prdm8, Prdm9, and Prdm16). In addition, Prdm1, Prdm5, and Prdm6 lack intrinsic HKMTase activity, but instead recruit G9a/Ehmt2/KMT1C, a strong mammalian histone H3 lysine 9 (H3K9) methyltransferase, to mediate HKMTase activity (see Fog et al., 2012 for a review). Another structural feature is that the Prdm family has multiple kruppel-type zinc finger (ZF) domains in the C-terminus involved in sequence-specific DNA binding and protein-protein interactions. |
| Status of entry | # |
| Expression range: | 0.0 to 392.05 |
| Mean expression: | 13.37 ± 32.46 |
| Median expression: | 3.17 |