| HGNC approved symbol | RNF2 |
| HGNC ID | HGNC:10061 |
| HGNC approved name | ring finger protein 2 |
| Entrez gene ID | GeneID:6045 (SSTAR profile) |
| UniProt AC (human) | Q99496 |
| UniProt ID (human) | RING2_HUMAN |
| Pfam domains | zf-C3HC4_2 PF13923 (50-90) RAWUL PF16207 (246-330) |
| MGI symbol | Rnf2 |
| MGI ID | MGI:1101759 |
| UniProt AC (mouse) | Q9CQJ4 |
| UniProt ID (mouse) | RING2_MOUSE |
| HGNC gene family tag | RNF |
| HGNC gene family description | RING-type (C3HC4) zinc fingers |
| Function | Histone modification write |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:16943429 |
| Protein complex | PRC1, BCOR, RING2-L3MBTL2, RING2-FBRS, CHD8, MLL2/3, MLL4/WBP7 |
| Target molecule | histone |
| Target entity | H2AK119 |
| Product | H2AK119ub |
| PMID for information on target | PMID:16943429 |
| Comment | RNF2 is the only BCOR complex PcG protein with a known enzymatic activity: an E3 ligase for the histone protein H2A (12, 78). Ub-H2A is thought to be involved in maintaining a repressed chromatin state. |
| Status of entry | # |
| Expression range: | 0.68 to 160.82 |
| Mean expression: | 28.07 ± 18.6 |
| Median expression: | 24.04 |