| HGNC approved symbol | BRD2 |
| HGNC ID | HGNC:1103 |
| HGNC approved name | bromodomain containing 2 |
| Entrez gene ID | GeneID:6046 (SSTAR profile) |
| UniProt AC (human) | P25440 |
| UniProt ID (human) | BRD2_HUMAN |
| Pfam domains | Bromodomain PF00439 (85-167, 354-440) BET PF17035 (640-704) |
| MGI symbol | Brd2 |
| MGI ID | MGI:99495 |
| UniProt AC (mouse) | Q7JJ13 |
| UniProt ID (mouse) | BRD2_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification read |
| Modification | # |
| PMID for information on function | PMID:18406326, PMID:20495584 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K9me2, H3K14me2, H4K5ac, H4K12ac, H3K27ac |
| Product | # |
| PMID for information on target | PMID:18406326, PMID:20495584 |
| Comment | Brd2- and Brd3-associated chromatin is significantly enriched in H4K5, H4K12, and H3K14 acetylation and contains relatively little dimethylated H3K9. Both Brd2 and Brd3 allowed RNA polymerase II to transcribe through nucleosomes in a defined transcription system. Such activity depended on specific histone H4 modifications known to be recognized by the Brd proteins.. BRD2 is involved in recognizing acetylated lysines, including H3K27ac, and its involvement in transcriptional regulation. |
| Status of entry | # |
| Expression range: | 26.79 to 579.65 |
| Mean expression: | 94.55 ± 56.99 |
| Median expression: | 77.9 |