Gene info
| HGNC approved symbol | PRDM16 |
| HGNC ID | HGNC:14000 |
| HGNC approved name | PR domain containing 16 |
| Entrez gene ID | GeneID:63976 (SSTAR profile) |
| UniProt AC (human) | Q9HAZ2 |
| UniProt ID (human) | PRD16_HUMAN |
| Pfam domains | PRDM2_PR PF21549 (84-212) zf-C2H2_6 PF13912 (230-250) zf-C2H2 PF00096 (281-303, 309-331, 337-360, 366-388, 394-416, 424-443, 951-973, 979-1002, 1008-1030) |
| MGI symbol | Prdm16 |
| MGI ID | MGI:1917923 |
| UniProt AC (mouse) | A2A935 |
| UniProt ID (mouse) | PRD16_MOUSE |
| HGNC gene family tag | ZNF |
| HGNC gene family description | Zinc fingers, C2H2-type |
| Function | Histone modification write cofactor, TF |
| Modification | Histone methylation, TF repressor |
| PMID for information on function | PMID:12816872, PMID:23856557 |
| Protein complex | # |
| Target molecule | histone, DNA |
| Target entity | H3K9, DNA motif |
| HOCOMOCO TFBS model | |
| Product | H3K9me |
| PMID for information on target | PMID:23856557 |
| Comment | The Prdm family may possess HKMTase properties. Some Prdms show intrinsic HKMTase activity (Prdm2, Prdm3, Prdm8, Prdm9, and Prdm16). In addition, Prdm1, Prdm5, and Prdm6 lack intrinsic HKMTase activity, but instead recruit G9a/Ehmt2/KMT1C, a strong mammalian histone H3 lysine 9 (H3K9) methyltransferase, to mediate HKMTase activity (see Fog et al., 2012 for a review). Another structural feature is that the Prdm family has multiple kruppel-type zinc finger (ZF) domains in the C-terminus involved in sequence-specific DNA binding and protein-protein interactions. |
| Status of entry | # |
Expression statistics
| Expression range: | 0.0 to 38.64 |
| Mean expression: | 1.71 ± 4.23 |
| Median expression: | 0.0 |