| HGNC approved symbol | TAF1 |
| HGNC ID | HGNC:11535 |
| HGNC approved name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
| Entrez gene ID | GeneID:6872 (SSTAR profile) |
| UniProt AC (human) | P21675 |
| UniProt ID (human) | TAF1_HUMAN |
| Pfam domains | TBP-binding PF09247 (27-87) DUF3591 PF12157 (589-1050) zf-CCHC_6 PF15288 (1282-1324) Bromodomain PF00439 (1411-1492, 1538-1613) |
| MGI symbol | Taf1 |
| MGI ID | MGI:1336878 |
| UniProt AC (mouse) | Q80UV9 |
| UniProt ID (mouse) | TAF1_MOUSE |
| HGNC gene family tag | KAT |
| HGNC gene family description | Chromatin-modifying enzymes / K-acetyltransferases |
| Function | Histone modification write |
| Modification | Histone acetylation |
| PMID for information on function | PMID:11295558 |
| Protein complex | CHD8, MLL2/3, MLL4/WBP7 |
| Target molecule | histone |
| Target entity | H3, H4 |
| Product | H3ac, H4ac |
| PMID for information on target | PMID:11295558 |
| Comment | TAFII250 has histone acetyltransferase (HAT) activity and can acetylate the tails of the core histones H3 and H4 in vitro. Both the N- and C-terminal kinase domains of TAFII250 are required for efficient transphosphorylation of RAP74 on serine residues. This suggests that the targeted phosphorylation of RAP74 by TAFII250 may provide a mechanism for signaling between components within the initiation complex to regulate transcription. |
| Status of entry | # |
| Expression range: | 1.46 to 55.18 |
| Mean expression: | 19.45 ± 10.41 |
| Median expression: | 17.59 |