| HGNC approved symbol | TLE4 |
| HGNC ID | HGNC:11840 |
| HGNC approved name | transducin-like enhancer of split 4 |
| Entrez gene ID | GeneID:7091 (SSTAR profile) |
| UniProt AC (human) | Q04727 |
| UniProt ID (human) | TLE4_HUMAN |
| Pfam domains | TLE_N PF03920 (24-138) WD40 PF00400 (480-514, 534-561, 580-605, 610-647, 695-728, 742-769) |
| MGI symbol | Tle4 |
| MGI ID | MGI:104633 |
| UniProt AC (mouse) | Q62441 |
| UniProt ID (mouse) | TLE4_MOUSE |
| HGNC gene family tag | WDR |
| HGNC gene family description | WD repeat domain containing |
| Function | Histone modification erase cofactor, TF |
| Modification | # |
| PMID for information on function | PMID:24190972 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3ac, H4ac |
| HOCOMOCO TFBS model | |
| Product | # |
| PMID for information on target | PMID:24190972 |
| Comment | Tle4 is the transcriptional repressor responsible for the establishment of the epigenetic repressive marks at the Ifng locus that result in silencing of Ifng gene expression. Tle proteins have been shown to oligomerize, to associate with amino-terminal domains of histone-modifying proteins, and to form higher-order structures as parts of repressive complexes. |
| Status of entry | # |
| Expression range: | 0.0 to 566.92 |
| Mean expression: | 49.68 ± 62.06 |
| Median expression: | 28.16 |