HGNC approved symbol | TTK |
HGNC ID | HGNC:12401 |
HGNC approved name | TTK protein kinase |
Entrez gene ID | GeneID:7272 (SSTAR profile) |
UniProt AC (human) | P33981 |
UniProt ID (human) | TTK_HUMAN |
Pfam domains | Pkinase PF00069 (525-791) |
MGI symbol | Ttk |
MGI ID | MGI:1194921 |
UniProt AC (mouse) | P35761 |
UniProt ID (mouse) | TTK_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write cofactor |
Modification | Histone phosphorylation |
PMID for information on function | PMID:22732840 |
Protein complex | # |
Target molecule | histone |
Target entity | H2AT120 |
Product | H2AT120ph |
PMID for information on target | PMID:22732840 |
Comment | Mps1 = TTK activity enhances H2A‐T120ph and is critical for Sgo1 recruitment to centromeres, thereby promoting Aurora B centromere recruitment in early mitosis. |
Status of entry | # |