HGNC approved symbol | KDM6A |
HGNC ID | HGNC:12637 |
HGNC approved name | lysine (K)-specific demethylase 6A |
Entrez gene ID | GeneID:7403 (SSTAR profile) |
UniProt AC (human) | O15550 |
UniProt ID (human) | KDM6A_HUMAN |
Pfam domains | TPR_8 PF13181 (205-237) JmjC PF02373 (1133-1241) KDM6_C-hel PF21322 (1248-1303) KDM6_GATAL PF21326 (1320-1380) |
MGI symbol | Kdm6a |
MGI ID | MGI:1095419 |
UniProt AC (mouse) | O70546 |
UniProt ID (mouse) | KDM6A_MOUSE |
HGNC gene family tag | KDM, TTC |
HGNC gene family description | Chromatin-modifying enzymes / K-demethylases, Tetratricopeptide (TTC) repeat domain containing |
Function | Histone modification erase |
Modification | Histone methylation |
PMID for information on function | PMID:17851529 |
Protein complex | CHD8, MLL2/3, MLL4/WBP7, COMPASS-like MLL3,4 |
Target molecule | histone |
Target entity | H3K27me2. H3K27me3 |
Product | H3K27 |
PMID for information on target | PMID:17851529 |
Comment | The JmjC-domain-containing proteins UTX=KDM6A and JMJD3 catalyse demethylation of H3K27me3/2. |
Status of entry | # |
Expression range: | 0.0 to 158.56 |
Mean expression: | 19.05 ± 18.92 |
Median expression: | 11.97 |