HGNC approved symbol | MLLT10 |
HGNC ID | HGNC:16063 |
HGNC approved name | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 |
Entrez gene ID | GeneID:8028 (SSTAR profile) |
UniProt AC (human) | P55197 |
UniProt ID (human) | AF10_HUMAN |
Pfam domains | PHD_2 PF13831 (37-72) zf-HC5HC2H_2 PF13832 (80-197) |
MGI symbol | Mllt10 |
MGI ID | MGI:1329038 |
UniProt AC (mouse) | O54826 |
UniProt ID (mouse) | AF10_MOUSE |
HGNC gene family tag | PHF |
HGNC gene family description | Zinc fingers, PHD-type |
Function | Histone modification write cofactor |
Modification | Histone methylation |
PMID for information on function | PMID:20203130 |
Protein complex | # |
Target molecule | histone |
Target entity | H3K79 |
Product | H3K79me3 |
PMID for information on target | PMID:20203130 |
Comment | MLLT10 =AF10 plays an important role in Dot1’s HMTase activity through either DotCom stability, catalytic activity, or the recruitment of the complex to chromatin. |
Status of entry | # |
Expression range: | 1.4 to 92.45 |
Mean expression: | 16.27 ± 9.52 |
Median expression: | 14.06 |