| HGNC approved symbol | SETD7 |
| HGNC ID | HGNC:30412 |
| HGNC approved name | SET domain containing (lysine methyltransferase) 7 |
| Entrez gene ID | GeneID:80854 (SSTAR profile) |
| UniProt AC (human) | Q8WTS6 |
| UniProt ID (human) | SETD7_HUMAN |
| Pfam domains | MORN PF02493 (19-34, 36-58, 60-81) domain PF22648 (110-184) SET PF00856 (227-336) |
| MGI symbol | Setd7 |
| MGI ID | MGI:1920501 |
| UniProt AC (mouse) | Q8VHL1 |
| UniProt ID (mouse) | SETD7_MOUSE |
| HGNC gene family tag | KMT |
| HGNC gene family description | Chromatin-modifying enzymes / K-methyltransferases |
| Function | Histone modification write |
| Modification | Histone methylation |
| PMID for information on function | PMID:11779497 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K4 |
| Product | H3K4me1 |
| PMID for information on target | PMID:11779497 |
| Comment | SET7 methylates H3-K4 in vitro and in vivo. In addition, methylation of H3-K4 and H3-K9 inhibit each other. Furthermore, H3-K4 and H3-K9 methylation by SET7 and SUV39H1, respectively, have differential effects on subsequent histone acetylation by p300. May explain differential effects of H3-K4 and H3-K9 methylation on transcription. |
| Status of entry | # |
| Expression range: | 0.0 to 165.19 |
| Mean expression: | 37.06 ± 23.83 |
| Median expression: | 33.44 |